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Last uploaded: January 31, 2024

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Preferred Name	Ivermectin
Synonyms	MK-933 Stromectol Mectizan MK 933 MK933 Eqvalan Ivomec
Definitions	Oral preparation of ivermectin. A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.
ID	http://purl.bioontology.org/ontology/MESH/D007559
altLabel	MK-933 Stromectol Mectizan MK 933 MK933 Eqvalan Ivomec
AQL	AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR
cui	C0729041 C0022322 C0751253 C0729042 C0729040 C0723477
DC	1
definition	Oral preparation of ivermectin. A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.
DX	19870101
HN	1987; for MECTIZAN use IVERMECTIN (NM) 1987-1999
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528
Inverse of RB	70288-86-7 0
isa	http://purl.bioontology.org/ontology/MESH/D000977 http://purl.bioontology.org/ontology/MESH/D007306
LT	TRD
Machine permutation	1987; for MECTIZAN see IVERMECTIN 1987-1999
Mapped from	http://purl.bioontology.org/ontology/MESH/C034045 http://purl.bioontology.org/ontology/MESH/C048324 http://purl.bioontology.org/ontology/MESH/C414354 http://purl.bioontology.org/ontology/MESH/C517095 http://purl.bioontology.org/ontology/MESH/C098208 http://purl.bioontology.org/ontology/MESH/C068576 http://purl.bioontology.org/ontology/MESH/C108024 http://purl.bioontology.org/ontology/MESH/C047538 http://purl.bioontology.org/ontology/MESH/C100820 http://purl.bioontology.org/ontology/MESH/C023882 http://purl.bioontology.org/ontology/MESH/C022120 http://purl.bioontology.org/ontology/MESH/C101434 http://purl.bioontology.org/ontology/MESH/C092182 http://purl.bioontology.org/ontology/MESH/C092183 http://purl.bioontology.org/ontology/MESH/C092184 http://purl.bioontology.org/ontology/MESH/C000600373 http://purl.bioontology.org/ontology/MESH/C443359 http://purl.bioontology.org/ontology/MESH/C019264 http://purl.bioontology.org/ontology/MESH/C076958 http://purl.bioontology.org/ontology/MESH/C554435 http://purl.bioontology.org/ontology/MESH/C052102 http://purl.bioontology.org/ontology/MESH/C059895 http://purl.bioontology.org/ontology/MESH/C516854 http://purl.bioontology.org/ontology/MESH/C084101 http://purl.bioontology.org/ontology/MESH/C110477 http://purl.bioontology.org/ontology/MESH/C110476
MDA	19860616
MMR	20160701
MN	D02.540.576.500.997
notation	D007559
PA	D000977 D007306
prefLabel	Ivermectin
TERMUI	T022723 T362593 T362594 T362591 T627803 T362592
TH	NLM (2000) USAN (1979) INN (19XX) NLM (2006) BAN (19XX)
tui	T109 T121
subClassOf	http://purl.bioontology.org/ontology/MESH/D018942

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/RXNORM/995490	RXNORM	CUI
http://purl.bioontology.org/ontology/MSHFRE/D007559	MSHFRE	CUI
http://purl.bioontology.org/ontology/MSHFRE/D007559	MSHFRE	CUI
http://purl.bioontology.org/ontology/RXNORM/220057	RXNORM	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/96138006	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/RXNORM/6069	RXNORM	CUI
http://purl.bioontology.org/ontology/SNMI/C-56B62	SNMI	CUI
http://purl.bioontology.org/ontology/VANDF/4021046	VANDF	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006374	NDFRT	CUI
http://purl.bioontology.org/ontology/ATC/P02CF01	ATC	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148510	NDFRT	CUI
http://purl.bioontology.org/ontology/NDDF/005266	NDDF	CUI
http://purl.bioontology.org/ontology/SCTSPA/96138006	SCTSPA	CUI
http://purl.bioontology.org/ontology/ATC/D11AX22	ATC	CUI
http://purl.bioontology.org/ontology/SCTSPA/387559003	SCTSPA	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387559003	SNOMEDCT	CUI
http://purl.obolibrary.org/obo/CHEBI_6078	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_6078	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_6078	HOIP	LOOM
http://purl.obolibrary.org/obo/CHEBI_6078	CHEBI	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D007559	RH-MESH	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017186	PMAPP-PMO	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61796	NCIT	LOOM
http://purl.bioontology.org/ontology/RXNORM/6069	RXNORM	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.540.505.330	RH-MESH	LOOM
http://purl.bioontology.org/ontology/SNMI/C-56B62	SNMI	LOOM
http://purl.obolibrary.org/obo/CHEBI_6078	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_6078	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_6078	INBANCIDO	LOOM
http://purl.obolibrary.org/obo/CHEBI_6078	DINTO	LOOM
http://purl.obolibrary.org/obo/CHEBI_6078	COVID-19	LOOM
http://purl.obolibrary.org/obo/CHEBI_6078	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_6078	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_6078	CIDO	LOOM
http://purl.obolibrary.org/obo/CHEBI_6078	UPHENO	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148510	INBANCIDO	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148510	CIDO	LOOM
http://purl.bioontology.org/ontology/VANDF/4021046	VANDF	LOOM
https://go.drugbank.com/drugs/DB00602	MDM	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0022322	OCHV	LOOM
http://stirdf.jst.go.jp/id/200907064532800399	IOBC	LOOM
http://purl.jp/bio/4/id/200906076694686578	IOBC	LOOM
http://purl.bioontology.org/ontology/ATC/P02CF01	ATC	LOOM
http://purl.obolibrary.org/obo/OMIT_0008673	OMIT	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148510	NDFRT	LOOM
http://www.drugbank.ca/drugs/DB00602	FTC	LOOM
http://purl.bioontology.org/ontology/NDDF/005266	NDDF	LOOM
http://purl.obolibrary.org/obo/NCIT_C61796	BERO	LOOM
http://purl.bioontology.org/ontology/ATC/D11AX22	ATC	LOOM
http://purl.obolibrary.org/obo/MESH_D007559	BERO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#6982	OCHV	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387559003	SNOMEDCT	LOOM