Medical Subject Headings

Last uploaded: August 28, 2024

Preferred Name	Angiotensinogen
Synonyms	Renin Substrate Tetradecapeptide, Renin Substrate Renin Substrate Tetradecapeptide Hypertensinogen Renin-Substrate Serpin A8 Angiotensinogen (protein renin substrate) Proangiotensin SERPINA8
Definitions	A synthetic or processed 14-amino acid peptide that is used to measure RENIN activities. An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver in response to lowered blood pressure and secreted into blood circulation. Angiotensinogen is the inactive precursor of the ANGIOTENSINS produced in the body by successive enzyme cleavages. Cleavage of angiotensinogen by RENIN yields the decapeptide ANGIOTENSIN I. Further cleavage of angiotensin I (by ANGIOTENSIN CONVERTING ENZYME) yields the potent vasoconstrictor octapeptide ANGIOTENSIN II; and then, via other enzymes, other angiotensins also involved in the hemodynamic-regulating RENIN-ANGIOTENSIN SYSTEM.
ID	http://purl.bioontology.org/ontology/MESH/D000808
altLabel	Renin Substrate Tetradecapeptide, Renin Substrate Renin Substrate Tetradecapeptide Hypertensinogen Renin-Substrate Serpin A8 Angiotensinogen (protein renin substrate) Proangiotensin SERPINA8
AQL	AD AE AG AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
cui	C0003017 C0086906
DC	1
definition	A synthetic or processed 14-amino acid peptide that is used to measure RENIN activities. An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver in response to lowered blood pressure and secreted into blood circulation. Angiotensinogen is the inactive precursor of the ANGIOTENSINS produced in the body by successive enzyme cleavages. Cleavage of angiotensinogen by RENIN yields the decapeptide ANGIOTENSIN I. Further cleavage of angiotensin I (by ANGIOTENSIN CONVERTING ENZYME) yields the potent vasoconstrictor octapeptide ANGIOTENSIN II; and then, via other enzymes, other angiotensins also involved in the hemodynamic-regulating RENIN-ANGIOTENSIN SYSTEM.
DX	19870101
HN	87(75); was see under ANGIOTENSINS 1975-86
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000172 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528
Inverse of RB	11002-13-4 0
isa	http://purl.bioontology.org/ontology/MESH/D015842
Machine permutation	87; was see under ANGIOTENSINS 1975-86
Mapped from	http://purl.bioontology.org/ontology/MESH/C000610416 http://purl.bioontology.org/ontology/MESH/C079544 http://purl.bioontology.org/ontology/MESH/C515557 http://purl.bioontology.org/ontology/MESH/C045142 http://purl.bioontology.org/ontology/MESH/C039583 http://purl.bioontology.org/ontology/MESH/C055796 http://purl.bioontology.org/ontology/MESH/C534933 http://purl.bioontology.org/ontology/MESH/C534932 http://purl.bioontology.org/ontology/MESH/C534931
MDA	19741119
MMR	20200609
MN	D12.776.872.020 D12.776.811.070 D12.644.456.073.070 D12.644.861.020
notation	D000808
PA	D015842
prefLabel	Angiotensinogen
TERMUI	T002408 T002407 T002405 T734759 T001079484 T002406 T002404
TH	NLM (1975) UNK (19XX) NLM (2021) NLM (2010)
tui	T116 T123
subClassOf	http://purl.bioontology.org/ontology/MESH/D011498 http://purl.bioontology.org/ontology/MESH/D000809 http://purl.bioontology.org/ontology/MESH/D015843

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/CSP/2237-7280	CRISP	CUI
http://purl.bioontology.org/ontology/MSHFRE/D000808	MSHFRE	CUI
http://purl.bioontology.org/ontology/CSP/2237-7280	CRISP	CUI
http://purl.bioontology.org/ontology/LNC/MTHU008275	LOINC	CUI
http://purl.bioontology.org/ontology/SNMI/F-62330	SNMI	CUI
http://purl.bioontology.org/ontology/SCTSPA/54592005	SCTSPA	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000170315	NDFRT	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/54592005	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/LNC/LP15390-5	LOINC	CUI
http://purl.bioontology.org/ontology/MSHFRE/D000808	MSHFRE	CUI
http://purl.bioontology.org/ontology/CSP/2237-7280	CRISP	LOOM
http://purl.obolibrary.org/obo/PR_000003847	UPHENO	LOOM
http://purl.obolibrary.org/obo/CHEBI_2720	CHEBI	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.776.872.020	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.644.822.750.020	RH-MESH	LOOM
http://purl.obolibrary.org/obo/CHEBI_2720	BERO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D000808	RH-MESH	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0003017	OCHV	LOOM
http://purl.obolibrary.org/obo/MESH_D000808	BERO	LOOM
http://purl.bioontology.org/ontology/CSP/2237-7280	CRISP	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.644.861.020	RH-MESH	LOOM
http://www.ncbi.nlm.nih.gov/gene/11606	NIFSTD	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00021380	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU008275	LOINC	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C136723	NCIT	LOOM
http://purl.bioontology.org/ontology/SNMI/F-62330	SNMI	LOOM
http://purl.obolibrary.org/obo/OMIT_0002213	OMIT	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#1186	OCHV	LOOM
http://purl.obolibrary.org/obo/PR_000003847	PR	LOOM
http://purl.obolibrary.org/obo/PR_000003847	INBANCIDO	LOOM
http://purl.obolibrary.org/obo/PR_000003847	CIDO	LOOM
http://purl.obolibrary.org/obo/PR_000003847	NIFSTD	LOOM
http://purl.obolibrary.org/obo/PR_000003847	OBA	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.644.456.073.070	RH-MESH	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/54592005	SNOMEDCT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.776.811.070	RH-MESH	LOOM
http://www.orpha.net/ORDO/Orphanet_119535	ORDO	LOOM
http://purl.bioontology.org/ontology/OMIM/106150	OMIM	LOOM
http://purl.jp/bio/4/id/200906049967426380	IOBC	LOOM
http://purl.obolibrary.org/obo/NCIT_C136723	BERO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.776.645.750.020	RH-MESH	LOOM
http://purl.bioontology.org/ontology/LNC/LP15390-5	LOINC	LOOM