loading...| Preferred Name |
Tolvaptan |
|
| Synonyms |
7-Chloro-5-hydroxy-1-(2-methyl-4-(2-methylbenzoylamino)benzoyl)2,3,4,5-tetrahydro-1H-1-benzazepine |
|
| Definitions |
A benzazepine derivative and selective VASOPRESSIN V2 RECEPTOR antagonist that is used to treat euvolemic and hypervolemic HYPONATREMIA. It is also used in the treatment of rapidly progressing AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE to slow the rate of cyst development and renal insufficiency. |
|
| ID |
http://purl.bioontology.org/ontology/MESH/D000077602 |
|
| altLabel |
7-Chloro-5-hydroxy-1-(2-methyl-4-(2-methylbenzoylamino)benzoyl)2,3,4,5-tetrahydro-1H-1-benzazepine Samsca OPC 41061 Benzamide, N-(4-((7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl)-3-methylphenyl)-2-methyl- OPC41061 OPC-41061 |
|
| AQL |
AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR |
|
| cui |
C2710117 C1176308 C0762110 |
|
| DC |
1 |
|
| definition |
A benzazepine derivative and selective VASOPRESSIN V2 RECEPTOR antagonist that is used to treat euvolemic and hypervolemic HYPONATREMIA. It is also used in the treatment of rapidly progressing AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE to slow the rate of cyst development and renal insufficiency. |
|
| DX |
20190101 |
|
| HN |
2019 (1999) |
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 |
|
| Inverse of RB |
0 21G72T1950 |
|
| isa | ||
| LT |
TRD |
|
| Machine permutation |
2019; TOLVAPTAN was indexed under BENZAZEPINES 1999-2019 |
|
| MDA |
20180709 |
|
| MMR |
20180409 |
|
| MN |
D03.633.100.079.875 |
|
| notation |
D000077602 |
|
| PA |
D065092 |
|
| prefLabel |
Tolvaptan |
|
| RR |
150683-30-0 (Tolvaptan) |
|
| TERMUI |
T758005 T544421 T544422 T000940433 T000940434 |
|
| TH |
NLM (2009) NLM (1999) USAN (19XX) INN (19XX) NLM (2003) FDA SRS (2015) |
|
| tui |
T109 T121 |
|
| subClassOf |