loading...| Preferred Name |
Leflunomide |
|
| Synonyms |
HWA-486 |
|
| Definitions |
An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS. |
|
| ID |
http://purl.bioontology.org/ontology/MESH/D000077339 |
|
| altLabel |
HWA-486 SU101 N-(4-Trifluoromethyphenyl)-5-methylisoxazole-4-carboxamide Arava 4-Isoxazolecarboxamide, 5-methyl-N-(4-(trifluoromethyl)phenyl)- HWA486 HWA 486 |
|
| AQL |
AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR |
|
| cui |
C0063041 C0966994 C0718644 C0122694 |
|
| DC |
1 |
|
| definition |
An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS. |
|
| DX |
20190101 |
|
| HN |
2019 (1985) |
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 |
|
| Inverse of RB |
G162GK9U4W 0 |
|
| isa | ||
| LT |
TRD |
|
| Machine permutation |
2019; LEFLUNOMIDE was indexed under ISOXAZOLES 1991-2018; and under OXAZOLES 1985-1990 |
|
| MDA |
20180709 |
|
| MMR |
20180227 |
|
| MN |
D03.383.129.385.475 |
|
| notation |
D000077339 |
|
| PA |
D004791 D007166 |
|
| prefLabel |
Leflunomide |
|
| RR |
75706-12-6 (Leflunomide) |
|
| TERMUI |
T000939396 T000939397 T429403 T162175 T461991 T162174 |
|
| TH |
US USAN (1990) UK NLM (2000) NL CA ES NLM (1985) INN (19XX) DE AU FDA SRS (2015) FR IE |
|
| tui |
T109 T121 |
|
| subClassOf |