loading...| Preferred Name | Dabrafenib | |
| Synonyms |
GSK-2118436 Benzenesulfonamide, N-(3-(5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl)-2-fluorophenyl)-2,6-difluoro- BRAF Inhibitor GSK2118436 GSK-2118436A DABRAFENIB Dabrafenib GSK2118436 |
|
| Definitions |
An orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C82386 |
|
| Accepted_Therapeutic_Use_For |
metastatic non-small cell lung cancer (NSCLC) with BRAF V600E mutation |
|
| CAS_Registry |
1195765-45-7 |
|
| Chemical_Formula |
C23H20F3N5O2S2 |
|
| code |
C82386 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
An orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations. |
|
| Display_Name |
Dabrafenib |
|
| FDA_UNII_Code |
QGP4HA4G1B |
|
| has exact synonym |
GSK-2118436 Benzenesulfonamide, N-(3-(5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl)-2-fluorophenyl)-2,6-difluoro- BRAF Inhibitor GSK2118436 GSK-2118436A DABRAFENIB Dabrafenib GSK2118436 |
|
| imported from | ||
| in_subset |
http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C116977 http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C116978 http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C63923 http://purl.oboInOwllibrary.org/oboInOwl/NCIT_C157711 |
|
| label |
Dabrafenib |
|
| Legacy_Concept_Name |
BRAF_Inhibitor_GSK2118436 |
|
| PDQ_Closed_Trial_Search_ID |
641977 |
|
| PDQ_Open_Trial_Search_ID |
641977 |
|
| Preferred_Name |
Dabrafenib |
|
| prefixIRI |
NCIT:C82386 |
|
| prefLabel |
Dabrafenib |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C3467876 |
|
| subClassOf |