Sexual dysfunction is defined as any of a group of sexual disorders, signs, or symptoms describing a decrease either of sexual desire or of the psychophysiological changes that usually characterize the sexual response. These encompass sexual desire disorders, sexual arousal disorders, orgasmic disorders, ejaculatory dysfunction, sexual pain disorders, substance/drug-induced sexual dysfunction, and sexual dysfunction due to a general medical condition. Common symptoms include: diminished genital sensation, pleasureless or weak orgasm, anorgasmia, decreased sex drive, inability to achieve erection, premature ejaculation, impaired lubrication, and diminished nipple sensation. Common causes include: altered anatomy or physiology (e.g., pelvic organ prolapse, impotence), nicotine, alcohol, and recreational drug use, hormonal abnormalities or changes, psychiatric disorders including depression, systemic illness, and medications. Medications that can cause sexual dysfunction include: hormonal contraceptives, antidepressants, including selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs), antiandrogens, 5-alpha reductase inhibitors, opioid analgesics, retinoids. For some medications, sexual side effects may persist even after treatment withdrawal.