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Medical Dictionary for Regulatory Activities Terminology (MedDRA)
| Id | http://purl.bioontology.org/ontology/MEDDRA/20000132
http://purl.bioontology.org/ontology/MEDDRA/20000132
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| Preferred Name | Noninfectious encephalitis (SMQ) |
| Definitions |
Encephalitis is defined as inflammation of the brain. Commonly has an infectious etiology. May also be drug-induced (focus of this SMQ). Mixed disorders such as encephalomyelitis, encephalomyeloradiculitis, or encephalo-myelopathy may present with overlapping symptoms. Signs and symptoms include: acute febrile illness characteristic of meningitis; confusion; behavioral abnormalities, including frank psychosis; altered level of consciousness; focal or generalized seizures; and focal neurological disturbances including aphasia, ataxia, hemiparesis, involuntary movements, cranial nerve deficits. Involvement of the hypothalamic-pituitary axis may result in temperature dysregulation, diabetes insipidus, or development of SIADH. Characteristic cerebrospinal fluid (CSF) profile consists of lymphocytic pleocytosis, mildly elevated protein concentration and normal glucose concentration. MRI, CT, and EEG abnormalities may occur.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Encephalitis is defined as inflammation of the brain. Commonly has an infectious etiology. May also be drug-induced (focus of this SMQ). Mixed disorders such as encephalomyelitis, encephalomyeloradiculitis, or encephalo-myelopathy may present with overlapping symptoms. Signs and symptoms include: acute febrile illness characteristic of meningitis; confusion; behavioral abnormalities, including frank psychosis; altered level of consciousness; focal or generalized seizures; and focal neurological disturbances including aphasia, ataxia, hemiparesis, involuntary movements, cranial nerve deficits. Involvement of the hypothalamic-pituitary axis may result in temperature dysregulation, diabetes insipidus, or development of SIADH. Characteristic cerebrospinal fluid (CSF) profile consists of lymphocytic pleocytosis, mildly elevated protein concentration and normal glucose concentration. MRI, CT, and EEG abnormalities may occur. |
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| prefLabel | Noninfectious encephalitis (SMQ)
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| SMQ STATUS | A
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| type | |
| tui | T185
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| notation | 20000132
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| SMQ LEVEL | 1
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| Semantic type UMLS property | |
| SMQ ALGO | N
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| cui | C1964001
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| SMQ SOURCE | 1) Andreoli T, Behrman R, Bhattacharya B et al. Dorland's Illustrated Medical Dictionary, 30th edition, dated 2003. Saunders, Philadelphia. 2) Beehrs M and Berkow R. The Merck Manual of Diagnosis and Therapy. 17th edition; 1999: 1431-42. 3) Kasper D, Braunwald E, Fauci A, et al. Harrison's Principles of Internal Medicine. 16th edition, 2005, page 2480-83.
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