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Breast Tissue Cell Lines Ontology
Last uploaded:
July 29, 2010
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Preferred Name | Proinsulin | |
Synonyms |
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ID |
http://purl.obolibrary.org/obo/MCBCC_0000013#Proinsulin |
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isDefinedBy |
A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the pancreatic beta cells, is comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide are the secreted products. Intact proinsulin with low bioactivity also is secreted in small amounts.
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prefixIRI |
MCBCC_0000013:Proinsulin
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prefLabel |
Proinsulin
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subClassOf |
http://purl.obolibrary.org/obo/MCBCC_0000012#PancreaticHormone |
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