loading...| Preferred Name |
hydroxychloroquine |
|
| Synonyms |
2-[{4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethanol hydroxychloroquinum 7-chloro-4-[5-(N-ethyl-N-2-hydroxyethylamino)-2-pentyl]aminoquinoline 7-chloro-4-[4-(N-ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino]quinoline 7-chloro-4-(4-(N-ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino)quinoline hydroxychloroquine oxichlorochine hidroxicloroquina (+-)-hydroxychloroquine Polirreumin 2-(N-(4-(7-chlor-4-chinolylamino)-4-methylbutyl)ethylamino)ethanol 7-chloro-4-(4-(ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline oxichloroquine NSC4375 2-((4-((7-chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol |
|
| Definitions |
An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_5801 |
|
| charge |
0 |
|
| chemical has protein target | ||
| chemical inhibits in vitro invasion of virus | ||
| database_cross_reference |
PMCID:PMC7122276 PMID:23216212 LINCS:LSM-5193 PMID:32311324 Reaxys:253894 PMID:32327429 PMID:32295814 PMID:23887202 PMID:32215614 CAS:118-42-3 PMID:23218706 Wikipedia:Hydroxychloroquine PMID:23581274 Patent:US2546658 Drug_Central:1395 PMID:32269046 PMID:23778483 KEGG:D08050 PMID:23481418 PMID:32294807 DrugBank:DB01611 PMID:23485647 HMDB:HMDB0015549 PMID:32283236 PMID:23902281 PMID:32295788 KEGG:C07043 |
|
| definition |
An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions. |
|
| definition source |
https://www.drugbank.ca/drugs/DB01611 PMID: 32150618; PMID: 32205204 |
|
| formula |
C18H26ClN3O |
|
| has exact synonym |
2-[{4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethanol |
|
| has functional parent | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_149553 http://purl.obolibrary.org/obo/CHEBI_50177 |
|
| has_obo_namespace |
chebi_ontology |
|
| has_related_synonym |
hydroxychloroquinum 7-chloro-4-[5-(N-ethyl-N-2-hydroxyethylamino)-2-pentyl]aminoquinoline 7-chloro-4-[4-(N-ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino]quinoline 7-chloro-4-(4-(N-ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino)quinoline hydroxychloroquine oxichlorochine hidroxicloroquina (+-)-hydroxychloroquine Polirreumin 2-(N-(4-(7-chlor-4-chinolylamino)-4-methylbutyl)ethylamino)ethanol 7-chloro-4-(4-(ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline oxichloroquine NSC4375 2-((4-((7-chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol |
|
| id |
CHEBI:5801 |
|
| imported from | ||
| in_subset | ||
| inchi |
InChI=1S/C18H26ClN3O/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21) |
|
| inchikey |
XXSMGPRMXLTPCZ-UHFFFAOYSA-N |
|
| is conjugate base of | ||
| label |
hydroxychloroquine |
|
| mass |
335.87200 |
|
| monoisotopicmass |
335.17644 |
|
| notation |
CHEBI:5801 |
|
| prefLabel |
hydroxychloroquine |
|
| smiles |
CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12 |
|
| susceptible to adverse event | ||
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_50995 http://purl.obolibrary.org/obo/CHEBI_36709 http://purl.obolibrary.org/obo/CHEBI_36683 |