Human Reference Atlas

Last uploaded: June 14, 2024
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Preferred Name

Macrophage
Synonyms

histiocyte
Definitions

A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells. Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid.
ID

http://purl.obolibrary.org/obo/CL_0000235
comment

Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid.
altLabel

histiocyte
ccf_ct_isa

http://purl.obolibrary.org/obo/CL_0000000
ccf_is_provisional

false
ccf_located_in

https://purl.org/ccf/ASCTB-TEMP_tonsil-germinal-center-mantle-zone

http://purl.obolibrary.org/obo/UBERON_0000059

https://purl.org/ccf/ASCTB-TEMP_lamina-propria-of-fallopian-tube-intramural-segment

http://purl.obolibrary.org/obo/UBERON_0002373

http://purl.obolibrary.org/obo/UBERON_8410066

http://purl.obolibrary.org/obo/UBERON_0000399

http://purl.obolibrary.org/obo/UBERON_0003889

https://purl.org/ccf/ASCTB-TEMP_lamina-propria-of-fallopian-tube-isthmus

http://purl.obolibrary.org/obo/UBERON_0000029

http://purl.obolibrary.org/obo/UBERON_0007324

http://purl.obolibrary.org/obo/UBERON_0009708

http://purl.obolibrary.org/obo/UBERON_0002006

http://purl.obolibrary.org/obo/UBERON_0002007

http://purl.obolibrary.org/obo/UBERON_0015834

http://purl.obolibrary.org/obo/UBERON_0001264

http://purl.obolibrary.org/obo/UBERON_0001153

http://purl.obolibrary.org/obo/UBERON_0001159

http://purl.obolibrary.org/obo/UBERON_0001154

http://purl.obolibrary.org/obo/UBERON_0001157

http://purl.obolibrary.org/obo/UBERON_0001156

http://purl.obolibrary.org/obo/UBERON_0001158

http://purl.obolibrary.org/obo/UBERON_0001961

http://purl.obolibrary.org/obo/UBERON_0001962

https://purl.org/ccf/ASCTB-TEMP_lamina-propria-fallopian-tube-ampulla

https://purl.org/ccf/ASCTB-TEMP_tonsil-secondary-follicle

http://purl.obolibrary.org/obo/UBERON_0004928

http://purl.obolibrary.org/obo/UBERON_0004927

http://purl.org/sig/ont/fma/fma7272

http://purl.obolibrary.org/obo/UBERON_8410074

http://purl.obolibrary.org/obo/UBERON_0016632

http://purl.obolibrary.org/obo/UBERON_0003379

http://purl.obolibrary.org/obo/UBERON_0013688

http://purl.org/sig/ont/fma/fma7206

https://purl.org/ccf/ASCTB-TEMP_lamina-propria-of-fallopian-tube-fimbria

http://purl.obolibrary.org/obo/UBERON_0002190

http://purl.obolibrary.org/obo/UBERON_0000006

http://purl.obolibrary.org/obo/UBERON_0000320

http://purl.obolibrary.org/obo/UBERON_0003984

http://purl.obolibrary.org/obo/UBERON_0006566

http://purl.obolibrary.org/obo/UBERON_0006567

http://purl.obolibrary.org/obo/UBERON_0003342

http://purl.obolibrary.org/obo/UBERON_8410010

http://purl.obolibrary.org/obo/UBERON_0001069

https://purl.org/ccf/ASCTB-TEMP_lamina-propria-gut-associated-lymphoid-tissue-galt-

http://purl.org/sig/ont/fma/fma83532

http://purl.obolibrary.org/obo/UBERON_0000317

http://purl.obolibrary.org/obo/UBERON_0000314

http://purl.obolibrary.org/obo/UBERON_0002094

http://purl.obolibrary.org/obo/UBERON_0002097

http://purl.obolibrary.org/obo/UBERON_0009745

http://purl.obolibrary.org/obo/UBERON_0009744

https://purl.org/ccf/ASCTB-TEMP_mucosa

http://purl.org/sig/ont/fma/fma14966

http://purl.obolibrary.org/obo/UBERON_0002067

http://purl.obolibrary.org/obo/UBERON_0000016

http://purl.obolibrary.org/obo/UBERON_0000017

http://purl.obolibrary.org/obo/UBERON_0000159

https://purl.org/ccf/ASCTB-TEMP_tonsil-follicle

http://purl.obolibrary.org/obo/UBERON_0004989

http://purl.obolibrary.org/obo/UBERON_0012648

http://purl.obolibrary.org/obo/UBERON_0000948

https://purl.org/ccf/ASCTB-TEMP_intramural-segment-of-fallopian-tube

http://purl.obolibrary.org/obo/UBERON_0010754

http://purl.org/sig/ont/fma/fma55221

http://purl.obolibrary.org/obo/UBERON_0022276

http://purl.obolibrary.org/obo/UBERON_0022277

http://purl.obolibrary.org/obo/UBERON_0000569

http://purl.obolibrary.org/obo/UBERON_0010395

http://purl.obolibrary.org/obo/UBERON_0001978

http://purl.obolibrary.org/obo/UBERON_0001245

http://purl.obolibrary.org/obo/UBERON_0001052

http://purl.obolibrary.org/obo/UBERON_0002108

http://purl.obolibrary.org/obo/UBERON_0003331

https://purl.org/ccf/ASCTB-TEMP_lamina-propria-of-fallopian-tube-infundibulum

http://purl.org/sig/ont/fma/fma83539

http://purl.obolibrary.org/obo/UBERON_0002079

http://purl.obolibrary.org/obo/UBERON_0002072

http://purl.obolibrary.org/obo/UBERON_0002078

http://purl.obolibrary.org/obo/UBERON_0002114

http://purl.obolibrary.org/obo/UBERON_0002115

http://purl.obolibrary.org/obo/UBERON_0003329

http://purl.obolibrary.org/obo/UBERON_0002080

http://purl.obolibrary.org/obo/UBERON_0002084

http://purl.obolibrary.org/obo/UBERON_0002348
ccf_pref_label

Macrophage

macrophage
definition

A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.
has exact synonym

histiocyte
in_subset

http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas

http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim

http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim

http://purl.obolibrary.org/obo/cl#cellxgene_subset
isDefinedBy

http://purl.obolibrary.org/obo/cl.owl
label

macrophage
prefixIRI

CL:0000235
prefLabel

Macrophage

macrophage

macrophages
present in taxon

http://purl.obolibrary.org/obo/NCBITaxon_9606
xRef

FMA:83585

FMA:63261

BTO:0000801

ZFA:0009141

MESH:D008264

CALOHA:TS-0587
subClassOf

http://purl.obolibrary.org/obo/CL_0000145

http://purl.obolibrary.org/obo/CL_0000113

http://purl.obolibrary.org/obo/CL_0000766
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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CL_0000235 VO SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 CL SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 UBERON SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 EUPATH SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 CLO SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 OBI SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 OHPI SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 CCONT SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 HOIP SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 CHEAR SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 NGBO SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 ONE SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 EFO SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 EGO SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 DOID SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 COVID-19 SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 PCL SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 MONDO SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 NIFDYS SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 GO-PLUS SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 BERO SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 EFO SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 HHEAR SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 TXPO SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 INO SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 UPHENO SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 OBI_IEE SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 NIFSTD SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 KTAO SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 HINO SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 OPL SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 IDODEN SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 VO SAME_URI
http://purl.obolibrary.org/obo/CL_0000235 OBA SAME_URI
http://purl.bioontology.org/ontology/HL7/C1550652 HL7 LOOM
http://purl.bioontology.org/ontology/LNC/MTHU016340 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#A15.382.812.522 RH-MESH LOOM
http://purl.obolibrary.org/obo/OMIT_0009339 OMIT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#7648 OCHV LOOM
https://pat.nichd.nih.gov/placentalcelltype/CT.02.03 PATCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#A15.382.680.397 RH-MESH LOOM
http://purl.obolibrary.org/obo/MESH_D008264 BERO LOOM
http://localhost/plosthes.2017-1#4278 PLOSTHES LOOM
http://purl.bioontology.org/ontology/MESH/D008264 MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#A11.627.482 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/LP14314-6 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D008264 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#A11.733.397 RH-MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00000670 PMAPP-PMO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#A11.329.372 RH-MESH LOOM
http://id.nlm.nih.gov/mesh/D008264 MDM LOOM