loading...| Preferred Name |
Mast Cell |
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| Synonyms |
labrocyte mastocyte histaminocyte tissue basophil |
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| Definitions |
Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5. A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development. |
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| ID |
http://purl.obolibrary.org/obo/CL_0000097 |
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| comment |
Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5. |
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| ccf_ct_isa | ||
| ccf_is_provisional |
false |
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| ccf_located_in |
http://purl.obolibrary.org/obo/UBERON_0000059 https://purl.org/ccf/ASCTB-TEMP_lamina-propria-of-fallopian-tube-intramural-segment http://purl.obolibrary.org/obo/UBERON_0002370 http://purl.obolibrary.org/obo/UBERON_0002371 http://purl.obolibrary.org/obo/UBERON_8410066 http://purl.obolibrary.org/obo/UBERON_0000399 http://purl.obolibrary.org/obo/UBERON_0003889 https://purl.org/ccf/ASCTB-TEMP_lamina-propria-of-fallopian-tube-isthmus http://purl.obolibrary.org/obo/UBERON_0000029 http://purl.obolibrary.org/obo/UBERON_0002006 http://purl.obolibrary.org/obo/UBERON_0002007 http://purl.obolibrary.org/obo/UBERON_0015834 http://purl.obolibrary.org/obo/UBERON_0001153 http://purl.obolibrary.org/obo/UBERON_0001159 http://purl.obolibrary.org/obo/UBERON_0001154 http://purl.obolibrary.org/obo/UBERON_0001157 http://purl.obolibrary.org/obo/UBERON_0001156 http://purl.obolibrary.org/obo/UBERON_0001158 http://purl.obolibrary.org/obo/UBERON_0002122 http://purl.obolibrary.org/obo/UBERON_0001961 http://purl.obolibrary.org/obo/UBERON_0001962 https://purl.org/ccf/ASCTB-TEMP_lamina-propria-fallopian-tube-ampulla http://purl.obolibrary.org/obo/UBERON_0003383 http://purl.obolibrary.org/obo/UBERON_8410075 http://purl.obolibrary.org/obo/UBERON_0016632 http://purl.org/sig/ont/fma/fma7206 https://purl.org/ccf/ASCTB-TEMP_lamina-propria-of-fallopian-tube-fimbria http://purl.obolibrary.org/obo/UBERON_0002190 http://purl.obolibrary.org/obo/UBERON_0000320 http://purl.obolibrary.org/obo/UBERON_0003984 http://purl.obolibrary.org/obo/UBERON_0006566 http://purl.obolibrary.org/obo/UBERON_0006567 http://purl.obolibrary.org/obo/UBERON_0003342 http://purl.obolibrary.org/obo/UBERON_8410010 https://purl.org/ccf/ASCTB-TEMP_lamina-propria-gut-associated-lymphoid-tissue-galt- http://purl.obolibrary.org/obo/UBERON_0000317 http://purl.obolibrary.org/obo/UBERON_0000314 http://purl.obolibrary.org/obo/UBERON_0002094 http://purl.obolibrary.org/obo/UBERON_0002097 http://purl.obolibrary.org/obo/UBERON_0009745 https://purl.org/ccf/ASCTB-TEMP_mucosa http://purl.org/sig/ont/fma/fma14966 http://purl.obolibrary.org/obo/UBERON_0002067 http://purl.obolibrary.org/obo/UBERON_0000159 http://purl.obolibrary.org/obo/UBERON_0004989 http://purl.obolibrary.org/obo/UBERON_0012648 http://purl.obolibrary.org/obo/UBERON_0000948 https://purl.org/ccf/ASCTB-TEMP_intramural-segment-of-fallopian-tube http://purl.obolibrary.org/obo/UBERON_0022276 http://purl.obolibrary.org/obo/UBERON_0022277 http://purl.obolibrary.org/obo/UBERON_0005215 http://purl.obolibrary.org/obo/UBERON_0000569 http://purl.obolibrary.org/obo/UBERON_0001245 http://purl.obolibrary.org/obo/UBERON_0001052 http://purl.obolibrary.org/obo/UBERON_0002108 http://purl.obolibrary.org/obo/UBERON_0004791 https://purl.org/ccf/ASCTB-TEMP_lamina-propria-of-fallopian-tube-infundibulum http://purl.org/sig/ont/fma/fma83539 http://purl.obolibrary.org/obo/UBERON_0002079 http://purl.obolibrary.org/obo/UBERON_0002072 http://purl.obolibrary.org/obo/UBERON_0002078 http://purl.obolibrary.org/obo/UBERON_0002114 http://purl.obolibrary.org/obo/UBERON_0002113 http://purl.obolibrary.org/obo/UBERON_0002115 http://purl.obolibrary.org/obo/UBERON_0002080 |
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| ccf_pref_label |
Mast Cell mast cell Mast cell |
|
| definition |
A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development. |
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| has exact synonym |
labrocyte mastocyte histaminocyte |
|
| has related synonym |
tissue basophil |
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| in_subset |
http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim |
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| isDefinedBy | ||
| label |
mast cell |
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| prefixIRI |
CL:0000097 |
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| prefLabel |
Mast Cell mast cell Mast cell mast cells |
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| present in taxon | ||
| xRef |
FMA:66784 BTO:0000830 CALOHA:TS-0603 |
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| subClassOf |