loading...| Preferred Name | Steroid-resistant nephrotic syndrome | |
| Synonyms |
SRNS |
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| Definitions |
A form of nephrotic syndrome that does not respond to treatment with steroid medication, defined as persistent proteinuria despite 60mg/m2 or 2mg/kg for 8 weeks, after insuring no infection or non-adherence to medication. Genetic studies and biopsy are necessary. Treatment depends on result. Genetic forms are treated symptomatically with ACE-inhibitor or angiotensin receptor blockers. Non-genetic forms are usually treated with calcineurin inhibitors. Prognosis is worse than in SSNS. 50 % progress into end-stage renal disease. |
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| ID |
http://purl.obolibrary.org/obo/HP_0012588 |
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| comment |
Genetic studies and biopsy are necessary. Treatment depends on result. Genetic forms are treated symptomatically with ACE-inhibitor or angiotensin receptor blockers. Non-genetic forms are usually treated with calcineurin inhibitors. Prognosis is worse than in SSNS. 50 % progress into end-stage renal disease. |
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| creation_date |
2014-01-16T03:47:57Z |
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| database_cross_reference |
SNOMEDCT_US:236381000 UMLS:C0403397 |
|
| definition |
A form of nephrotic syndrome that does not respond to treatment with steroid medication, defined as persistent proteinuria despite 60mg/m2 or 2mg/kg for 8 weeks, after insuring no infection or non-adherence to medication. |
|
| has_exact_synonym |
SRNS |
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| has_obo_namespace |
human_phenotype |
|
| id |
HP:0012588 |
|
| label |
Steroid-resistant nephrotic syndrome |
|
| notation |
HP:0012588 |
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| prefLabel |
Steroid-resistant nephrotic syndrome |
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| terms_creator | ||
| treeView | ||
| subClassOf |