loading...| Preferred Name | Gray matter heterotopia | |
| Synonyms |
Gray matter heterotopias Grey matter heterotopia Heterotopia Heterotopias Grey matter heterotopias Neuronal heterotopia |
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| Definitions |
Heterotopia or neuronal heterotopia are macroscopic clusters of misplaced neurons (gray matter), most often situated along the ventricular walls or within the subcortical white matter. Gray matter heterotopia is caused by clumps of gray matter being located in the wrong part of the brain. It is characterized as a type of cortical malformation. The neurons in heterotopia may appear to be normal, except for their mislocation; nuclear studies have shown glucose metabolism equal to that of normally positioned gray matter. The condition causes a variety of symptoms, but usually includes some degree of epilepsy or recurring seizures, and often affects the brain's ability to function on higher levels. Symptoms range from nonexistent to profound, in which case heterotopia can result in severe seizure disorder, loss of motor skills, and mental retardation. Neuronal heterotopia consists of gray matter within the white matter, and the term gray matter heterotopia is more frequently used. |
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| ID |
http://purl.obolibrary.org/obo/HP_0002282 |
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| comment |
Gray matter heterotopia is caused by clumps of gray matter being located in the wrong part of the brain. It is characterized as a type of cortical malformation. The neurons in heterotopia may appear to be normal, except for their mislocation; nuclear studies have shown glucose metabolism equal to that of normally positioned gray matter. The condition causes a variety of symptoms, but usually includes some degree of epilepsy or recurring seizures, and often affects the brain's ability to function on higher levels. Symptoms range from nonexistent to profound, in which case heterotopia can result in severe seizure disorder, loss of motor skills, and mental retardation. Neuronal heterotopia consists of gray matter within the white matter, and the term gray matter heterotopia is more frequently used. |
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| database_cross_reference |
SNOMEDCT_US:416286003 UMLS:C0008519 SNOMEDCT_US:128490007 SNOMEDCT_US:417338002 |
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| definition |
Heterotopia or neuronal heterotopia are macroscopic clusters of misplaced neurons (gray matter), most often situated along the ventricular walls or within the subcortical white matter. |
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| has_alternative_id |
HP:0002281 HP:0007314 |
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| has_exact_synonym |
Gray matter heterotopias Grey matter heterotopia Heterotopia Heterotopias Grey matter heterotopias Neuronal heterotopia |
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| has_obo_namespace |
human_phenotype |
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| id |
HP:0002282 |
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| label |
Gray matter heterotopia |
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| notation |
HP:0002282 |
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| prefLabel |
Gray matter heterotopia |
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| treeView | ||
| subClassOf |