Meiosis

Reviewed: Bolcun-Filas, E, 2011-02-25 Authored: May, B, 2011-08-19 Reviewed: Lyndaker, A, 2011-02-25 Reviewed: Strong, E, 2011-02-25 Reviewed: Cohen, PE, 2011-02-04 Reviewed: Holloway, JK, 2011-02-04 Edited: May, B, 2011-08-19 During meiosis the replicated chromosomes of a single diploid cell are segregated into 4 haploid daughter cells by two successive divisions, meiosis I and meiosis II. In meiosis I, the distinguishing event of meiosis, pairs (bivalents) of homologous chromosomes in the form of sister chromatids are paired, synapsed along their regions of homologous DNA (reviewed in Yang and Wang 2009), and then segregated, resulting in haploid daughters containing sister chromatids paired at their centromeres (reviewed in Cohen et al. 2006, Handel and Schimenti 2010). The sister chromatids are then separated and segregated during meiosis II.<br>Recombination between chromosomal homologues but not between sister chromatids occurs during prophase of meiosis I (reviewed in Inagaki et al. 2010). Though hundreds of recombination events are initiated, most are resolved without crossovers and only tens proceed to become crossovers. In mammals recombination events are required between homologues for normal pairing, synapsis, and segregation. Reviewed: Schimenti, JC, 2011-02-04

http://purl.obolibrary.org/obo/HINO_0027107

Reviewed: Bolcun-Filas, E, 2011-02-25

Authored: May, B, 2011-08-19

Reviewed: Lyndaker, A, 2011-02-25

Reviewed: Strong, E, 2011-02-25

Reviewed: Cohen, PE, 2011-02-04

Reviewed: Holloway, JK, 2011-02-04

Edited: May, B, 2011-08-19

During meiosis the replicated chromosomes of a single diploid cell are segregated into 4 haploid daughter cells by two successive divisions, meiosis I and meiosis II. In meiosis I, the distinguishing event of meiosis, pairs (bivalents) of homologous chromosomes in the form of sister chromatids are paired, synapsed along their regions of homologous DNA (reviewed in Yang and Wang 2009), and then segregated, resulting in haploid daughters containing sister chromatids paired at their centromeres (reviewed in Cohen et al. 2006, Handel and Schimenti 2010). The sister chromatids are then separated and segregated during meiosis II.
Recombination between chromosomal homologues but not between sister chromatids occurs during prophase of meiosis I (reviewed in Inagaki et al. 2010). Though hundreds of recombination events are initiated, most are resolved without crossovers and only tens proceed to become crossovers. In mammals recombination events are required between homologues for normal pairing, synapsis, and segregation.

Reviewed: Schimenti, JC, 2011-02-04

Pubmed16543383

Pubmed20051984

Pubmed20364103

Reactome, http://www.reactome.org

Pubmed18948708

Meiosis

http://purl.obolibrary.org/obo/NCBITaxon_9606

HINO:0027107

Meiosis

Reactome Database ID Release 431500620

ReactomeREACT_111183

http://purl.obolibrary.org/obo/INO_0000021

http://purl.obolibrary.org/obo/HINO_0027108

http://purl.obolibrary.org/obo/HINO_0017719