Reviewed: Bolcun-Filas, E, 2011-02-25 Reviewed: Lyndaker, A, 2011-02-25 Reviewed: Strong, E, 2011-02-25 Edited: May, B, 2011-02-25 Reviewed: Cohen, PE, 2011-02-04 Reviewed: Holloway, JK, 2011-02-04 Meiotic synapsis is the stable physical pairing of homologous chromosomes that begins in leptonema of prophase I and lasts until anaphase of prophase I. First, short segments of axial elements form along chromosomes. Telomeres then cluster at a region of the inner nuclear membrane and axial elements extend and fuse along the length of the chromosomes. Subsequent to the initiation of recombination transverse filaments of SYCP1 link axial/lateral elements to a central element containing SYCE1 and SYCE2, thus forming the synaptonemal complex (reviewed in Yang and Wang 2009).<br>Unsynapsed regions are silenced during pachynema by recruitment of BRCA1 and ATR, which phosphorylates histone H2AX (reviewed in Inagaki et al. 2010). Reviewed: Schimenti, JC, 2011-02-04 Authored: May, B, 2011-02-25

http://purl.obolibrary.org/obo/HINO_0017719

Reviewed: Bolcun-Filas, E, 2011-02-25

Reviewed: Lyndaker, A, 2011-02-25

Reviewed: Strong, E, 2011-02-25

Edited: May, B, 2011-02-25

Reviewed: Cohen, PE, 2011-02-04

Reviewed: Holloway, JK, 2011-02-04

Meiotic synapsis is the stable physical pairing of homologous chromosomes that begins in leptonema of prophase I and lasts until anaphase of prophase I. First, short segments of axial elements form along chromosomes. Telomeres then cluster at a region of the inner nuclear membrane and axial elements extend and fuse along the length of the chromosomes. Subsequent to the initiation of recombination transverse filaments of SYCP1 link axial/lateral elements to a central element containing SYCE1 and SYCE2, thus forming the synaptonemal complex (reviewed in Yang and Wang 2009).
Unsynapsed regions are silenced during pachynema by recruitment of BRCA1 and ATR, which phosphorylates histone H2AX (reviewed in Inagaki et al. 2010).

Reviewed: Schimenti, JC, 2011-02-04

Authored: May, B, 2011-02-25

Pubmed20364103

Reactome, http://www.reactome.org

Pubmed18948708

Meiotic Synapsis

http://purl.obolibrary.org/obo/NCBITaxon_9606

HINO:0017719

Meiotic Synapsis

Reactome Database ID Release 431221632

ReactomeREACT_75792

http://purl.obolibrary.org/obo/INO_0000021

http://purl.obolibrary.org/obo/HINO_0010796

http://purl.obolibrary.org/obo/HINO_0010795

http://purl.obolibrary.org/obo/HINO_0010793

http://purl.obolibrary.org/obo/HINO_0010794

http://purl.obolibrary.org/obo/HINO_0010797

http://purl.obolibrary.org/obo/HINO_0010798