loading...| Preferred Name |
Raf activation |
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| Synonyms |
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| Definitions |
Raf is a downstream effector of ras. Raf is activated upon phosphorylation at S338, oligomerization and membrane localization. Membrane localization is facilitated by ras. Interaction of ras with raf is a necessary step but not sufficient for raf activation. Other unknown protein partner interactions are required for raf activation. Raf further activates MAP kinase. Authored: Mahajan, SS, 2009-10-29 Edited: Gillespie, ME, 2009-06-02 00:56:21 Reviewed: Tukey, D, 2009-11-17 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0026934 |
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| comment |
Raf is a downstream effector of ras. Raf is activated upon phosphorylation at S338, oligomerization and membrane localization. Membrane localization is facilitated by ras. Interaction of ras with raf is a necessary step but not sufficient for raf activation. Other unknown protein partner interactions are required for raf activation. Raf further activates MAP kinase. Authored: Mahajan, SS, 2009-10-29 Edited: Gillespie, ME, 2009-06-02 00:56:21 Reviewed: Tukey, D, 2009-11-17 |
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| definition source |
Pubmed19727074 Pubmed17603483 Reactome, http://www.reactome.org Pubmed12062470 Pubmed17064357 |
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| label |
Raf activation |
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| prefixIRI |
HINO:0026934 |
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| prefLabel |
Raf activation |
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| seeAlso |
Reactome Database ID Release 43442726 ReactomeREACT_20578 |
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