Link to this page
Human Interaction Network Ontology
Last uploaded:
June 27, 2014
Jump to:
| Preferred Name | Ubiquitin-dependent degradation of Cyclin D1 | |
| Synonyms |
|
|
| Definitions |
After the Cyclin D serves the role of mediating reactions by Cdk4 and Cdk6, it is shuttled to the cytoplasm and degraded in a ubiquitin-dependent manner. Whether Cdk4 and Cdk6 are truly redundant is a topic still under investigation, although both the kinases are required for normal cell cycle progression.<p>Destruction of the D type cyclins accompanies the end of the G1 phase, and the E type cyclins are involved in transition of the cell from G1 to S phase. |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0017653 |
|
| comment |
After the Cyclin D serves the role of mediating reactions by Cdk4 and Cdk6, it is shuttled to the cytoplasm and degraded in a ubiquitin-dependent manner. Whether Cdk4 and Cdk6 are truly redundant is a topic still under investigation, although both the kinases are required for normal cell cycle progression.<p>Destruction of the D type cyclins accompanies the end of the G1 phase, and the E type cyclins are involved in transition of the cell from G1 to S phase.
|
|
| definition source |
Reactome, http://www.reactome.org
|
|
| label |
Ubiquitin-dependent degradation of Cyclin D1
|
|
| located_in | ||
| prefixIRI |
HINO:0017653
|
|
| prefLabel |
Ubiquitin-dependent degradation of Cyclin D1
|
|
| seeAlso |
ReactomeREACT_4 Reactome Database ID Release 4369229
|
|
| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0011522 http://purl.obolibrary.org/obo/HINO_0011523 http://purl.obolibrary.org/obo/HINO_0011505 |
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |