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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | E2F-enabled inhibition of pre-replication complex formation | |
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| Definitions |
Under specific conditions, Cyclin B, a mitotic cyclin, can inhibit the functions of pre-replicative complex. E2F1 activates Cdc25A protein which regulates Cyclin B in a positive manner. Cyclin B/Cdk1 function is restored which leads to the disruption of pre-replicative complex. This phenomenon has been demonstrated by Bosco et al (2001) in Drosophila. Authored: Gopinathrao, G, 2004-05-26 17:05:00 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0017639 |
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| comment |
Under specific conditions, Cyclin B, a mitotic cyclin, can inhibit the functions of pre-replicative complex. E2F1 activates Cdc25A protein which regulates Cyclin B in a positive manner. Cyclin B/Cdk1 function is restored which leads to the disruption of pre-replicative complex. This phenomenon has been demonstrated by Bosco et al (2001) in Drosophila. Authored: Gopinathrao, G, 2004-05-26 17:05:00
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| definition source |
Pubmed11231579 Reactome, http://www.reactome.org Pubmed11090133
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| label |
E2F-enabled inhibition of pre-replication complex formation
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| prefixIRI |
HINO:0017639
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| prefLabel |
E2F-enabled inhibition of pre-replication complex formation
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| seeAlso |
Reactome Database ID Release 43113507 ReactomeREACT_1321
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