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Human Interaction Network Ontology
| Preferred Name | O-linked glycosylation of mucins | |
| Synonyms |
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| Definitions |
Reviewed: Ferrer, A, 2011-11-04 Authored: Jassal, B, 2010-07-19 Edited: Jassal, B, 2010-07-19 Mucins are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most metazoa. Mucins' key characteristic is their ability to form gels; therefore they are a key component in most gel-like secretions, serving functions from lubrication to cell signalling to forming chemical barriers. To date, there are approximately 20 genes that express mucins. Mature mucins are composed of two distinct regions:<br>(1) The amino- and carboxy-terminal regions are very lightly glycosylated, but rich in cysteines. The cysteine residues participate in establishing disulfide linkages within and among mucin monomers.<br>(2) A large central region rich in serine, threonine and proline residues called the variable number of tandem repeat (VNTR) region which can become heavily O-glycosylated with hundreds of O-GalNAc glycans.<br> N-acetyl-galactosamine (GalNAc) is the first glycan to be attached, forming the simplest mucin O-glycan. After this, several different pathways are possible generating "core" structures. Four core structures are commonly formed, several others are possible but infrequent. O-linked glycans are often capped by the addition of a sialic acid residue, terminating the addition of any more O-glycans (Brockhausen et al, 2009; Tarp and Clausen, 2008). |
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| ID |
http://purl.obolibrary.org/obo/HINO_0016810 |
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| comment |
Reviewed: Ferrer, A, 2011-11-04 Authored: Jassal, B, 2010-07-19 Edited: Jassal, B, 2010-07-19 Mucins are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most metazoa. Mucins' key characteristic is their ability to form gels; therefore they are a key component in most gel-like secretions, serving functions from lubrication to cell signalling to forming chemical barriers. To date, there are approximately 20 genes that express mucins. Mature mucins are composed of two distinct regions:<br>(1) The amino- and carboxy-terminal regions are very lightly glycosylated, but rich in cysteines. The cysteine residues participate in establishing disulfide linkages within and among mucin monomers.<br>(2) A large central region rich in serine, threonine and proline residues called the variable number of tandem repeat (VNTR) region which can become heavily O-glycosylated with hundreds of O-GalNAc glycans.<br> N-acetyl-galactosamine (GalNAc) is the first glycan to be attached, forming the simplest mucin O-glycan. After this, several different pathways are possible generating "core" structures. Four core structures are commonly formed, several others are possible but infrequent. O-linked glycans are often capped by the addition of a sialic acid residue, terminating the addition of any more O-glycans (Brockhausen et al, 2009; Tarp and Clausen, 2008).
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| definition source |
Pubmed20301232 Reactome, http://www.reactome.org Pubmed17988798
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| label |
O-linked glycosylation of mucins
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| located_in | ||
| prefixIRI |
HINO:0016810
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| prefLabel |
O-linked glycosylation of mucins
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| seeAlso |
Reactome Database ID Release 43913709 ReactomeREACT_115606 GENE ONTOLOGYGO:0016266
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| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0025649 http://purl.obolibrary.org/obo/HINO_0025648 http://purl.obolibrary.org/obo/HINO_0025647 http://purl.obolibrary.org/obo/HINO_0025655 http://purl.obolibrary.org/obo/HINO_0025654 http://purl.obolibrary.org/obo/HINO_0025651 http://purl.obolibrary.org/obo/HINO_0025653 http://purl.obolibrary.org/obo/HINO_0025652 http://purl.obolibrary.org/obo/HINO_0025650 |
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