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Human Interaction Network Ontology
| Preferred Name | Post-chaperonin tubulin folding pathway | |
| Synonyms |
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| Definitions |
Reviewed: Cowan, NJ, 2009-01-21 16:47:24 Edited: Matthews, L, 2009-02-21 04:38:35 Authored: Matthews, L, 2008-12-01 04:46:41 Alpha and beta tubulin folding intermediates are formed through ATPâdependent interaction with TriC/CCT. In order to form a functional heterodimer, these folding intermediates undergo a series of interactions with five proteins: (cofactors A-E) following release from TriC/CCT (reviewed in Cowan and Lewis et al., 2001). These interactions are described in the reactions below. Ultimately, alpha tubulin, when associated with cofactor E, interacts with cofactor D-bound beta-tubulin. The entry of cofactor C into this complex results in the discharge of native heterodimer triggered by GTP hydrolysis in beta tubulin (Tian et al., 1997). |
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| ID |
http://purl.obolibrary.org/obo/HINO_0016749 |
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| comment |
Reviewed: Cowan, NJ, 2009-01-21 16:47:24 Edited: Matthews, L, 2009-02-21 04:38:35 Authored: Matthews, L, 2008-12-01 04:46:41 Alpha and beta tubulin folding intermediates are formed through ATPâdependent interaction with TriC/CCT. In order to form a functional heterodimer, these folding intermediates undergo a series of interactions with five proteins: (cofactors A-E) following release from TriC/CCT (reviewed in Cowan and Lewis et al., 2001). These interactions are described in the reactions below. Ultimately, alpha tubulin, when associated with cofactor E, interacts with cofactor D-bound beta-tubulin. The entry of cofactor C into this complex results in the discharge of native heterodimer triggered by GTP hydrolysis in beta tubulin (Tian et al., 1997).
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| definition source |
Reactome, http://www.reactome.org Pubmed11868281 Pubmed17709011 Pubmed9265649
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| label |
Post-chaperonin tubulin folding pathway
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| located_in | ||
| prefixIRI |
HINO:0016749
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| prefLabel |
Post-chaperonin tubulin folding pathway
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| seeAlso |
GENE ONTOLOGYGO:0007023 Reactome Database ID Release 43389977 ReactomeREACT_16967
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| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0025885 http://purl.obolibrary.org/obo/HINO_0025888 http://purl.obolibrary.org/obo/HINO_0025905 http://purl.obolibrary.org/obo/HINO_0025904 http://purl.obolibrary.org/obo/HINO_0025891 http://purl.obolibrary.org/obo/HINO_0025890 http://purl.obolibrary.org/obo/HINO_0025893 |
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