loading...| Preferred Name |
Post-chaperonin tubulin folding pathway |
|
| Synonyms |
|
|
| Definitions |
Reviewed: Cowan, NJ, 2009-01-21 16:47:24 Edited: Matthews, L, 2009-02-21 04:38:35 Authored: Matthews, L, 2008-12-01 04:46:41 Alpha and beta tubulin folding intermediates are formed through ATPâdependent interaction with TriC/CCT. In order to form a functional heterodimer, these folding intermediates undergo a series of interactions with five proteins: (cofactors A-E) following release from TriC/CCT (reviewed in Cowan and Lewis et al., 2001). These interactions are described in the reactions below. Ultimately, alpha tubulin, when associated with cofactor E, interacts with cofactor D-bound beta-tubulin. The entry of cofactor C into this complex results in the discharge of native heterodimer triggered by GTP hydrolysis in beta tubulin (Tian et al., 1997). |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0016749 |
|
| comment |
Reviewed: Cowan, NJ, 2009-01-21 16:47:24 Edited: Matthews, L, 2009-02-21 04:38:35 Authored: Matthews, L, 2008-12-01 04:46:41 Alpha and beta tubulin folding intermediates are formed through ATPâdependent interaction with TriC/CCT. In order to form a functional heterodimer, these folding intermediates undergo a series of interactions with five proteins: (cofactors A-E) following release from TriC/CCT (reviewed in Cowan and Lewis et al., 2001). These interactions are described in the reactions below. Ultimately, alpha tubulin, when associated with cofactor E, interacts with cofactor D-bound beta-tubulin. The entry of cofactor C into this complex results in the discharge of native heterodimer triggered by GTP hydrolysis in beta tubulin (Tian et al., 1997). |
|
| definition source |
Reactome, http://www.reactome.org Pubmed11868281 Pubmed17709011 Pubmed9265649 |
|
| label |
Post-chaperonin tubulin folding pathway |
|
| located_in | ||
| prefixIRI |
HINO:0016749 |
|
| prefLabel |
Post-chaperonin tubulin folding pathway |
|
| seeAlso |
GENE ONTOLOGYGO:0007023 Reactome Database ID Release 43389977 ReactomeREACT_16967 |
|
| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0025885 http://purl.obolibrary.org/obo/HINO_0025888 http://purl.obolibrary.org/obo/HINO_0025905 http://purl.obolibrary.org/obo/HINO_0025904 http://purl.obolibrary.org/obo/HINO_0025891 http://purl.obolibrary.org/obo/HINO_0025890 http://purl.obolibrary.org/obo/HINO_0025893 |