loading...| Preferred Name |
The activation of arylsulfatases |
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| Synonyms |
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| Definitions |
Sulfatase activity requires a unique posttranslational modification (PTM) of a catalytic cysteine residue into a formylglycine. This modification is impaired in patients with multiple sulfatase deficiency (MSD) due to defects in the SUMF1 (sulfatase-modifying factor 1) gene responsible for this PTM. SUMF2 can inhibit the activity of SUMF1 thereby providing a mechanism for the regulation of sulfatase activation (Ghosh 2007, Diez-Roux & Ballabio 2005). Reviewed: D'Eustachio, P, 2012-05-14 Edited: Jassal, B, 2011-10-14 Authored: Jassal, B, 2011-10-14 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0016723 |
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| comment |
Sulfatase activity requires a unique posttranslational modification (PTM) of a catalytic cysteine residue into a formylglycine. This modification is impaired in patients with multiple sulfatase deficiency (MSD) due to defects in the SUMF1 (sulfatase-modifying factor 1) gene responsible for this PTM. SUMF2 can inhibit the activity of SUMF1 thereby providing a mechanism for the regulation of sulfatase activation (Ghosh 2007, Diez-Roux & Ballabio 2005). Reviewed: D'Eustachio, P, 2012-05-14 Edited: Jassal, B, 2011-10-14 Authored: Jassal, B, 2011-10-14 |
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| definition source |
Pubmed17558559 Reactome, http://www.reactome.org Pubmed16124866 |
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| label |
The activation of arylsulfatases |
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| located_in | ||
| prefixIRI |
HINO:0016723 |
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| prefLabel |
The activation of arylsulfatases |
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| seeAlso |
ReactomeREACT_121036 Reactome Database ID Release 431663150 |
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