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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | SUMF2 inhibits SUMF1-mediated activation of arylsulfatases | |
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| Definitions |
Reviewed: D'Eustachio, P, 2012-05-14 Authored: Jassal, B, 2011-09-28 Sulfatase-modifying factor 2 (SUMF2, also called C-alpha-formylglycine-generating enzyme 2, pFGE) is the paralogue of SUMF1. While SUMF1 can modify a critical residue on arylsulfatases to confer activity to them, SUMF2 lacks this ability (Mariappan et al. 2005) and instead, SUMF2 can inhibit the action of SUMF1 by dimerising with it (Zito et al. 2005). SUMF2 can interact with sulfatases with and without SUMF1 (Zito et al. 2005). Edited: Jassal, B, 2011-09-28 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0025934 |
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| comment |
Reviewed: D'Eustachio, P, 2012-05-14 Authored: Jassal, B, 2011-09-28 Sulfatase-modifying factor 2 (SUMF2, also called C-alpha-formylglycine-generating enzyme 2, pFGE) is the paralogue of SUMF1. While SUMF1 can modify a critical residue on arylsulfatases to confer activity to them, SUMF2 lacks this ability (Mariappan et al. 2005) and instead, SUMF2 can inhibit the action of SUMF1 by dimerising with it (Zito et al. 2005). SUMF2 can interact with sulfatases with and without SUMF1 (Zito et al. 2005). Edited: Jassal, B, 2011-09-28
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| definition source |
Pubmed15708861 Reactome, http://www.reactome.org Pubmed15962010
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SUMF2 inhibits SUMF1-mediated activation of arylsulfatases
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| prefixIRI |
HINO:0025934
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SUMF2 inhibits SUMF1-mediated activation of arylsulfatases
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| seeAlso |
ReactomeREACT_121184 Reactome Database ID Release 431614336
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