loading...| Preferred Name | Processing of DNA ends prior to end rejoining | |
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Authored: Matthews, L, 2003-09-07 08:47:00 Ionizing radiation induced DNA double strand breaks often contain end groups that must be processed before the DNA can be rejoined. Possible candidate proteins for the processing steps include Artemis (a nuclease) (Ma and Lieber, 2002); WRN (a helicase with exonuclease activity) (Li and Comai, 2001; Yannone et al., 2002; Karmakar, et al., 2002a, 2002b); PNK (a 5'-OH kinase and 3'-phosphate phosphatase) (Chappell et al., 2002); the Mre11/Rad50/Nbs1 nuclease complex (D' Amours and Jackson, 2002); or hTdp1 (tyrosyl-DNA phosphodiesterase, which removes 3'-glycolates)(Inamdar et al., 2002; Valerie and Povirk, 2003). Precisely when processing of the DNA ends occurs during NHEJ is not known. |
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http://purl.obolibrary.org/obo/HINO_0016688 |
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Authored: Matthews, L, 2003-09-07 08:47:00 Ionizing radiation induced DNA double strand breaks often contain end groups that must be processed before the DNA can be rejoined. Possible candidate proteins for the processing steps include Artemis (a nuclease) (Ma and Lieber, 2002); WRN (a helicase with exonuclease activity) (Li and Comai, 2001; Yannone et al., 2002; Karmakar, et al., 2002a, 2002b); PNK (a 5'-OH kinase and 3'-phosphate phosphatase) (Chappell et al., 2002); the Mre11/Rad50/Nbs1 nuclease complex (D' Amours and Jackson, 2002); or hTdp1 (tyrosyl-DNA phosphodiesterase, which removes 3'-glycolates)(Inamdar et al., 2002; Valerie and Povirk, 2003). Precisely when processing of the DNA ends occurs during NHEJ is not known. |
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Reactome, http://www.reactome.org Pubmed11152456 Pubmed12032095 Pubmed12947387 Pubmed11955432 Pubmed11889123 Pubmed12023295 Pubmed12177300 Pubmed11477099 Pubmed11988766 |
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Processing of DNA ends prior to end rejoining |
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HINO:0016688 |
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Processing of DNA ends prior to end rejoining |
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Reactome Database ID Release 4375924 ReactomeREACT_1201 |
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