loading...| Preferred Name |
Signaling by activated point mutants of FGFR3 |
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| Synonyms |
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| Definitions |
Activating point mutations in FGFR3 are found in the extracellular ligand-binding domain, the transmembrane region and the tyrosine kinase domain and are believed to result in ligand-independent activation of the receptor (Webster and Donoghue, 1996; Wenbster, 1997). These mutations, although initially characterized in the context of autosomal skeletal disorders, are now being identified in a range of cancers including bladder, cervical, breast, prostate, head and neck, and multiple myeloma (reviewed in Wesche, 2011). Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0016278 |
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| comment |
Activating point mutations in FGFR3 are found in the extracellular ligand-binding domain, the transmembrane region and the tyrosine kinase domain and are believed to result in ligand-independent activation of the receptor (Webster and Donoghue, 1996; Wenbster, 1997). These mutations, although initially characterized in the context of autosomal skeletal disorders, are now being identified in a range of cancers including bladder, cervical, breast, prostate, head and neck, and multiple myeloma (reviewed in Wesche, 2011). Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
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| definition source |
Reactome, http://www.reactome.org Pubmed8599935 Pubmed21711248 Pubmed8754806 |
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| label |
Signaling by activated point mutants of FGFR3 |
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| located_in | ||
| prefixIRI |
HINO:0016278 |
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| prefLabel |
Signaling by activated point mutants of FGFR3 |
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| seeAlso |
Reactome Database ID Release 431839130 ReactomeREACT_121337 |
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| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0008101 http://purl.obolibrary.org/obo/HINO_0008100 http://purl.obolibrary.org/obo/HINO_0008102 http://purl.obolibrary.org/obo/HINO_0008097 |