loading...| Preferred Name |
Autocatalytic phosphorylation of FGFR3 cysteine mutants |
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| Definitions |
has a Stoichiometric coefficient of 12 Although each of FGFR3 R248C, S249C, G370C, S371C and Y373C have been shown to undergo ligand-independent dimerization and receptor autophosphorylation, there is conflicting evidence about which mutants also show increased phosphorylation upon ligand stimulation. Mutants showed elevated levels of ligand-independent MAPK pathway activation and supported expression of an in vivo reporter gene (d'Avis, 1998; Adar, 2009). Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
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http://purl.obolibrary.org/obo/HINO_0008096 |
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| comment |
has a Stoichiometric coefficient of 12 Although each of FGFR3 R248C, S249C, G370C, S371C and Y373C have been shown to undergo ligand-independent dimerization and receptor autophosphorylation, there is conflicting evidence about which mutants also show increased phosphorylation upon ligand stimulation. Mutants showed elevated levels of ligand-independent MAPK pathway activation and supported expression of an in vivo reporter gene (d'Avis, 1998; Adar, 2009). Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
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| definition source |
Pubmed12009017 Reactome, http://www.reactome.org Pubmed9438390 |
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| label |
Autocatalytic phosphorylation of FGFR3 cysteine mutants |
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| prefixIRI |
HINO:0008096 |
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| prefLabel |
Autocatalytic phosphorylation of FGFR3 cysteine mutants |
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| seeAlso |
Reactome Database ID Release 432012082 EC Number: 2.7.10 ReactomeREACT_120832 |
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