FGFR1 ligand binding and activation

Authored: de Bono, B, 2007-01-10 10:27:18 Edited: de Bono, B, D'Eustachio, P, 2007-02-10 20:21:22 The vertebrate fibroblast growth factor receptor 1 (FGFR1) is alternatively spliced generating multiple variants that are differentially expressed during embryo development and in the adult body. The restricted expression patterns of FGFR1 isoforms, together with differential expression and binding of specific ligands, leads to activation of common FGFR1 signal transduction pathways, but may result in distinctively different biological responses as a result of differences in cellular context. FGFR1 isoforms are also present in the nucleus in complex with various fibroblast growth factors where they function to regulate transcription of target genes.<br><br>FGFR is probably activated by NCAM very differently from the way by which it is activated by FGFs, reflecting the different conditions for NCAM–FGFR and FGF–FGFR interactions. The affinity of FGF for FGFR is approximately 10e6 times higher than that of NCAM for FGFR. Moreover, in the brain NCAM is constantly present on the cell surface at a much higher (micromolar) concentration than FGFs, which only appear transiently in the extracellular environment in the nanomolar range. Reviewed: Mohammadi, M, 2007-02-06 21:44:35

http://purl.obolibrary.org/obo/HINO_0016059

Authored: de Bono, B, 2007-01-10 10:27:18

Edited: de Bono, B, D'Eustachio, P, 2007-02-10 20:21:22

The vertebrate fibroblast growth factor receptor 1 (FGFR1) is alternatively spliced generating multiple variants that are differentially expressed during embryo development and in the adult body. The restricted expression patterns of FGFR1 isoforms, together with differential expression and binding of specific ligands, leads to activation of common FGFR1 signal transduction pathways, but may result in distinctively different biological responses as a result of differences in cellular context. FGFR1 isoforms are also present in the nucleus in complex with various fibroblast growth factors where they function to regulate transcription of target genes.

FGFR is probably activated by NCAM very differently from the way by which it is activated by FGFs, reflecting the different conditions for NCAM–FGFR and FGF–FGFR interactions. The affinity of FGF for FGFR is approximately 10e6 times higher than that of NCAM for FGFR. Moreover, in the brain NCAM is constantly present on the cell surface at a much higher (micromolar) concentration than FGFs, which only appear transiently in the extracellular environment in the nanomolar range.

Reviewed: Mohammadi, M, 2007-02-06 21:44:35

Pubmed16597617

Reactome, http://www.reactome.org

Pubmed12141425

Pubmed12791257

Pubmed16045455

FGFR1 ligand binding and activation

http://purl.obolibrary.org/obo/NCBITaxon_9606

HINO:0016059

FGFR1 ligand binding and activation

Reactome Database ID Release 43190242

ReactomeREACT_9483

GENE ONTOLOGYGO:0008543

http://purl.obolibrary.org/obo/INO_0000021

http://purl.obolibrary.org/obo/HINO_0016057

http://purl.obolibrary.org/obo/HINO_0016058