loading...| Preferred Name |
FGFR2 ligand binding and activation |
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Authored: de Bono, B, 2007-01-10 10:27:18 Edited: de Bono, B, D'Eustachio, P, 2007-02-10 20:21:22 Reviewed: Mohammadi, M, 2007-02-06 21:44:35 Dominant mutations in the fibroblast growth factor receptor 2 (FGFR2) gene have been identified as causes of four phenotypically distinct craniosynostosis syndromes, including Crouzon, Jackson- Weiss, Pfeiffer, and Apert syndromes. FGFR2 binds a number of different FGFs preferentially, as illustrated in this pathway.<br><br>FGFR is probably activated by NCAM very differently from the way by which it is activated by FGFs, reflecting the different conditions for NCAMâFGFR and FGFâFGFR interactions. The affinity of FGF for FGFR is approximately 10e6 times higher than that of NCAM for FGFR. Moreover, in the brain NCAM is constantly present on the cell surface at a much higher (micromolar) concentration than FGFs, which only appear transiently in the extracellular environment in the nanomolar range. |
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http://purl.obolibrary.org/obo/HINO_0016056 |
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Authored: de Bono, B, 2007-01-10 10:27:18 Edited: de Bono, B, D'Eustachio, P, 2007-02-10 20:21:22 Reviewed: Mohammadi, M, 2007-02-06 21:44:35 Dominant mutations in the fibroblast growth factor receptor 2 (FGFR2) gene have been identified as causes of four phenotypically distinct craniosynostosis syndromes, including Crouzon, Jackson- Weiss, Pfeiffer, and Apert syndromes. FGFR2 binds a number of different FGFs preferentially, as illustrated in this pathway. |
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| definition source |
Pubmed16844695 Pubmed16597617 Reactome, http://www.reactome.org Pubmed17133345 |
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FGFR2 ligand binding and activation |
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HINO:0016056 |
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FGFR2 ligand binding and activation |
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Reactome Database ID Release 43190241 GENE ONTOLOGYGO:0008543 ReactomeREACT_9390 |
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