loading...| Preferred Name | Cell redox homeostasis | |
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| Definitions |
Authored: Stephan, R, 2011-01-10 The most important response of <i>Mtb</i> to oxidative stress is provided by catalase and peroxiredoxins, both of which get their reducing equivalents through a network of disulfide proteins and, finally, from NAD(P)H. Multiple redundancies make choosing a good drug target difficult (Koul et al. 2011). Optimum efficacy can only be expected from inhibitors of the most upstream components of the redox cascades, i.e. the NAD(P)H-dependent reductases TrxB and Lpd (Jaeger & Flohe 2006). Reviewed: Warner, D, 2012-04-30 Edited: Jassal, B, 2011-02-28 |
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http://purl.obolibrary.org/obo/HINO_0015989 |
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| comment |
Authored: Stephan, R, 2011-01-10 The most important response of Mtb to oxidative stress is provided by catalase and peroxiredoxins, both of which get their reducing equivalents through a network of disulfide proteins and, finally, from NAD(P)H. Multiple redundancies make choosing a good drug target difficult (Koul et al. 2011). Optimum efficacy can only be expected from inhibitors of the most upstream components of the redox cascades, i.e. the NAD(P)H-dependent reductases TrxB and Lpd (Jaeger & Flohe 2006). Reviewed: Warner, D, 2012-04-30 Edited: Jassal, B, 2011-02-28 |
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| definition source |
Pubmed21270886 Pubmed17012768 Reactome, http://www.reactome.org |
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Cell redox homeostasis |
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| prefixIRI |
HINO:0015989 |
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| prefLabel |
Cell redox homeostasis |
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| seeAlso |
GENE ONTOLOGYGO:0045454 ReactomeREACT_121394 Reactome Database ID Release 431222541 |
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http://purl.obolibrary.org/obo/HINO_0004448 http://purl.obolibrary.org/obo/HINO_0004442 http://purl.obolibrary.org/obo/HINO_0004444 http://purl.obolibrary.org/obo/HINO_0004446 http://purl.obolibrary.org/obo/HINO_0004449 |