Preferred Name |
CaM pathway |
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Synonyms |
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Definitions |
Authored: Le Novere, N, Jassal, B, 2004-03-31 12:22:05 Edited: Jassal, B, 2008-11-06 10:17:49 Calmodulin (CaM) is a small acidic protein that contains four EF-hand motifs, each of which can bind a calcium ion, therefore it can bind up to four calcium ions. The protein has two approximately symmetrical domains, separated by a flexible hinge region. Calmodulin is the prototypical example of the EâF-hand family of Ca2+-sensing proteins. Changes in intracellular Ca2+ concentration regulate calmodulin in three distinct ways. First, by directing its subcellular distribution. Second, by promoting association with different target proteins. Third, by directing a variety of conformational states in calmodulin that result in target-specific activation. Calmodulin binds and activates several effector protein (e.g. the CaM-dependent adenylyl cyclases, phosphodiesterases, protein kinases and the protein phosphatase calcineurin). Reviewed: Castagnoli, L, 2008-11-06 12:55:54 |
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ID |
http://purl.obolibrary.org/obo/HINO_0015985 |
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comment |
Authored: Le Novere, N, Jassal, B, 2004-03-31 12:22:05 Edited: Jassal, B, 2008-11-06 10:17:49 Calmodulin (CaM) is a small acidic protein that contains four EF-hand motifs, each of which can bind a calcium ion, therefore it can bind up to four calcium ions. The protein has two approximately symmetrical domains, separated by a flexible hinge region. Calmodulin is the prototypical example of the EâF-hand family of Ca2+-sensing proteins. Changes in intracellular Ca2+ concentration regulate calmodulin in three distinct ways. First, by directing its subcellular distribution. Second, by promoting association with different target proteins. Third, by directing a variety of conformational states in calmodulin that result in target-specific activation. Calmodulin binds and activates several effector protein (e.g. the CaM-dependent adenylyl cyclases, phosphodiesterases, protein kinases and the protein phosphatase calcineurin). Reviewed: Castagnoli, L, 2008-11-06 12:55:54 |
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definition source |
Pubmed10884684 Reactome, http://www.reactome.org |
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label |
CaM pathway |
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located_in | ||
prefixIRI |
HINO:0015985 |
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prefLabel |
CaM pathway |
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seeAlso |
ReactomeREACT_9053 Reactome Database ID Release 43111997 |
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subClassOf | ||
has_part |
Delete | Mapping To | Ontology | Source |
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http://purl.obolibrary.org/obo/UPa_UPA00323 | UPA | LOOM | |
http://scai.fraunhofer.de/PWDICT#ID1564 | PTS | LOOM |