loading...| Preferred Name | EGFR interacts with phospholipase C-gamma | |
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| Definitions |
Reviewed: Heldin, CH, 2008-02-12 09:44:02 Activated epidermal growth factor receptors (EGFR) can stimulate phosphatidylinositol (PI) turnover. Activated EGFR can activate phospholipase C-gamma1 (PLC-gamma1, i.e. PLCG1) which hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). IP3 is instrumental in the release of calcium from intracellular stores and DAG is involved in protein kinase C activation. Authored: Jassal, B, 2008-02-13 11:13:12 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0015983 |
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| comment |
Reviewed: Heldin, CH, 2008-02-12 09:44:02 Activated epidermal growth factor receptors (EGFR) can stimulate phosphatidylinositol (PI) turnover. Activated EGFR can activate phospholipase C-gamma1 (PLC-gamma1, i.e. PLCG1) which hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). IP3 is instrumental in the release of calcium from intracellular stores and DAG is involved in protein kinase C activation. Authored: Jassal, B, 2008-02-13 11:13:12 |
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| definition source |
Reactome, http://www.reactome.org Pubmed1501243 |
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| label |
EGFR interacts with phospholipase C-gamma |
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HINO:0015983 |
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| prefLabel |
EGFR interacts with phospholipase C-gamma |
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| seeAlso |
GENE ONTOLOGYGO:0007165 ReactomeREACT_12478 Reactome Database ID Release 43212718 |
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http://purl.obolibrary.org/obo/HINO_0004498 http://purl.obolibrary.org/obo/HINO_0004495 |