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Human Interaction Network Ontology
| Preferred Name | CREB phosphorylation | |
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| Definitions |
Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Nerve growth factor (NGF) activates multiple signalling pathways that mediate the phosphorylation of CREB at the critical regulatory site, serine 133. CREB phosphorylation at serine 133 is a crucial event in neurotrophin signalling, being mediated by ERK/RSK, ERK/MSK1 and p38/MAPKAPK2 pathways. Several kinases, such as MSK1, RSK1/2/3 (MAPKAPK1A/B/C), and MAPKAPK2, are able to directly phosphorylate CREB at S133. MSK1 is also able to activate ATF (Cyclic-AMP-dependent transcription factor). However, the NGF-induced CREB phosphorylation appears to correlate better with activation of MSK1 rather than RSK1/2/3, or MAPKAPK2. In retrograde signalling, activation of CREB occurs within 20 minutes after neurotrophin stimulation of distal axons. Reviewed: Greene, LA, 2007-11-08 15:39:37 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0015713 |
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| comment |
Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Nerve growth factor (NGF) activates multiple signalling pathways that mediate the phosphorylation of CREB at the critical regulatory site, serine 133. CREB phosphorylation at serine 133 is a crucial event in neurotrophin signalling, being mediated by ERK/RSK, ERK/MSK1 and p38/MAPKAPK2 pathways. Several kinases, such as MSK1, RSK1/2/3 (MAPKAPK1A/B/C), and MAPKAPK2, are able to directly phosphorylate CREB at S133. MSK1 is also able to activate ATF (Cyclic-AMP-dependent transcription factor). However, the NGF-induced CREB phosphorylation appears to correlate better with activation of MSK1 rather than RSK1/2/3, or MAPKAPK2. In retrograde signalling, activation of CREB occurs within 20 minutes after neurotrophin stimulation of distal axons. Reviewed: Greene, LA, 2007-11-08 15:39:37
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| definition source |
Reactome, http://www.reactome.org
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| label |
CREB phosphorylation
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| located_in | ||
| prefixIRI |
HINO:0015713
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| prefLabel |
CREB phosphorylation
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| seeAlso |
ReactomeREACT_12524 Reactome Database ID Release 43199920
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http://purl.obolibrary.org/obo/HINO_0026372 http://purl.obolibrary.org/obo/HINO_0026374 |
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