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Human Interaction Network Ontology
| Preferred Name | Assembly of the ORC complex at the origin of replication | |
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| Definitions |
In Saccharomyces cerevisiae, the entire ORC complex is constitutively bound to the origin of replication. However, in mammalian cells, Orc1, and possibly other Orc subunits, dissociate from origins of replication, while Orc2 remains stably associated with chromatin across the cell cycle. The first step in formation of the pre-RC is assembly of the hexameric Origin Recognition Complex (ORC) at the origin of replication. Recent work on human (Hs) ORC has suggested that the heterohexamer assembles in an ordered manner. HsOrc2 appears to be constitutively bound to origins of replication. HsOrc2 and HsOrc3 form a complex that interacts with HsOrc4 and HsOrc5. Recruitment of HsOrc5 into the complex is important for the association of HsOrc1. HsOrc6 is also capable of interacting with the core HsOrc2:3:4:5 complex, but not smaller complexes. Interestingly, HsOrc1 and a subunit of the Mcm2-7 complex (HsMcm2) interact with a histone acetyltransferase, HsHBO1 (Bell & Stillman 1992; Diffley et al. 1994; Lee & Bell 1997; Wenger et al. 1975; Li & DePamphili;s 2001; Dhar et al. 2001; Vashee et al, 2001; Iizuka & Stillman 1999 Burke et al. 2001). Authored: Davey, MJ, O'Donnell, M, 2003-06-05 08:03:13 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0015401 |
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| comment |
In Saccharomyces cerevisiae, the entire ORC complex is constitutively bound to the origin of replication. However, in mammalian cells, Orc1, and possibly other Orc subunits, dissociate from origins of replication, while Orc2 remains stably associated with chromatin across the cell cycle. The first step in formation of the pre-RC is assembly of the hexameric Origin Recognition Complex (ORC) at the origin of replication. Recent work on human (Hs) ORC has suggested that the heterohexamer assembles in an ordered manner. HsOrc2 appears to be constitutively bound to origins of replication. HsOrc2 and HsOrc3 form a complex that interacts with HsOrc4 and HsOrc5. Recruitment of HsOrc5 into the complex is important for the association of HsOrc1. HsOrc6 is also capable of interacting with the core HsOrc2:3:4:5 complex, but not smaller complexes. Interestingly, HsOrc1 and a subunit of the Mcm2-7 complex (HsMcm2) interact with a histone acetyltransferase, HsHBO1 (Bell & Stillman 1992; Diffley et al. 1994; Lee & Bell 1997; Wenger et al. 1975; Li & DePamphili;s 2001; Dhar et al. 2001; Vashee et al, 2001; Iizuka & Stillman 1999 Burke et al. 2001). Authored: Davey, MJ, O'Donnell, M, 2003-06-05 08:03:13
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| definition source |
Pubmed11395502 Pubmed11739726 Reactome, http://www.reactome.org Pubmed11323433 Pubmed11278932 Pubmed9372948 Pubmed10438470 Pubmed8044842 Pubmed1579162 Pubmed1110244
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| label |
Assembly of the ORC complex at the origin of replication
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| located_in | ||
| prefixIRI |
HINO:0015401
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| prefLabel |
Assembly of the ORC complex at the origin of replication
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| seeAlso |
ReactomeREACT_567 Reactome Database ID Release 4368616
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http://purl.obolibrary.org/obo/HINO_0014855 http://purl.obolibrary.org/obo/HINO_0014859 http://purl.obolibrary.org/obo/HINO_0014846 |
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