loading...| Preferred Name | Effects of PIP2 hydrolysis | |
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Edited: Jupe, S, 2009-09-09 Hydrolysis of phosphatidyl inositol-bisphosphate (PIP2) by phospholipase C (PLC) produces diacylglycerol (DAG) and inositol triphosphate (IP3). Both are potent second messengers. IP3 diffuses into the cytosol, but as DAG is a hydrophobic lipid it remains within the plasma membrane. IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, while DAG activates the conventional and unconventional protein kinase C (PKC) isoforms, facilitating the translocation of PKC from the cytosol to the plasma membrane. The effects of DAG are mimicked by tumor-promoting phorbol esters. DAG is also a precursor for the biosynthesis of prostaglandins, the endocannabinoid 2-arachidonoylglycerol and an activator of a subfamily of TRP-C (Transient Receptor Potential Canonical) cation channels 3, 6, and 7. |
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http://purl.obolibrary.org/obo/HINO_0015334 |
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Edited: Jupe, S, 2009-09-09 Hydrolysis of phosphatidyl inositol-bisphosphate (PIP2) by phospholipase C (PLC) produces diacylglycerol (DAG) and inositol triphosphate (IP3). Both are potent second messengers. IP3 diffuses into the cytosol, but as DAG is a hydrophobic lipid it remains within the plasma membrane. IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, while DAG activates the conventional and unconventional protein kinase C (PKC) isoforms, facilitating the translocation of PKC from the cytosol to the plasma membrane. The effects of DAG are mimicked by tumor-promoting phorbol esters. DAG is also a precursor for the biosynthesis of prostaglandins, the endocannabinoid 2-arachidonoylglycerol and an activator of a subfamily of TRP-C (Transient Receptor Potential Canonical) cation channels 3, 6, and 7. |
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| definition source |
Pubmed17157506 Reactome, http://www.reactome.org Pubmed9601053 |
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Effects of PIP2 hydrolysis |
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HINO:0015334 |
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Effects of PIP2 hydrolysis |
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ReactomeREACT_2202 Reactome Database ID Release 43114508 |
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http://purl.obolibrary.org/obo/HINO_0014541 http://purl.obolibrary.org/obo/HINO_0014182 http://purl.obolibrary.org/obo/HINO_0014169 http://purl.obolibrary.org/obo/HINO_0014140 http://purl.obolibrary.org/obo/HINO_0014142 |