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Human Interaction Network Ontology
| Preferred Name | abacavir | |
| Synonyms |
Nc1nc(NC2CC2)c2ncn([C@@H]3C[C@H](CO)C=C3)c2n1 {(1S-cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol abacavir InChI=1S/C14H18N6O/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19)/t8-,10+/m1/s1 C14H18N6O InChIKey=MCGSCOLBFJQGHM-SCZZXKLOSA-N {(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol Abacavir |
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| Definitions |
(1S)-Cyclopent-2-en-1-ylmethanol in which the pro-R hydrogen at the 4-position is substituted by a 2-amino-6-(cyclopropylamino)-9H-purin-9-yl group. A nucleoside analogue reverse transcriptase inhibitor (NRTI) with antiretroviral activity against HIV, it is used (particularly as the sulfate) with other antiretrovirals in combination therapy of HIV infection. |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_421707 |
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| database_cross_reference |
ChEMBL:18029175 CiteXplore:18549801 ChEMBL:16759112 KEGG DRUG:D07057 KEGG COMPOUND:C07624 ChEMBL:12781181 ChEMBL:17870541 KEGG COMPOUND:136470-78-5 ChemIDplus:136470-78-5 ChEMBL:15887959 ChEMBL:16458506 Beilstein:7493116 ChEMBL:16539393 ChEMBL:17172311 Wikipedia:Abacavir CiteXplore:11678376 DrugBank:DB01048
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| definition |
(1S)-Cyclopent-2-en-1-ylmethanol in which the pro-R hydrogen at the 4-position is substituted by a 2-amino-6-(cyclopropylamino)-9H-purin-9-yl group. A nucleoside analogue reverse transcriptase inhibitor (NRTI) with antiretroviral activity against HIV, it is used (particularly as the sulfate) with other antiretrovirals in combination therapy of HIV infection.
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| has_alternative_id |
CHEBI:520984 CHEBI:441792 CHEBI:525912 CHEBI:2360 CHEBI:193608
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| has_exact_synonym |
{(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol Abacavir
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| has_obo_namespace |
chebi_ontology
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| has_related_synonym |
Nc1nc(NC2CC2)c2ncn([C@@H]3C[C@H](CO)C=C3)c2n1 {(1S-cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol abacavir InChI=1S/C14H18N6O/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19)/t8-,10+/m1/s1 C14H18N6O InChIKey=MCGSCOLBFJQGHM-SCZZXKLOSA-N
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| id |
CHEBI:421707
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| imported from | ||
| label |
abacavir
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| notation |
CHEBI:421707
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| prefixIRI |
CHEBI:421707
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| prefLabel |
abacavir
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| subClassOf |
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