loading...| Preferred Name |
enzalutamide |
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| Synonyms |
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| Definitions |
A benzamide obtained by formal condensation of the carboxy group of 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl}-2-fluorobenzoic acid with methylamine. Used for the treatment of of metastatic castration-resistant prostate cancer. |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_68534 |
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| ATC Code |
L02BB04 |
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| ChEBI ID | ||
| definition |
A benzamide obtained by formal condensation of the carboxy group of 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl}-2-fluorobenzoic acid with methylamine. Used for the treatment of of metastatic castration-resistant prostate cancer. An orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. Through a mechanism that is reported to be different from other approved AR antagonists, enzalutamide inhibits the activity of prostate cancer cell ARs, which may result in a reduction in prostate cancer cell proliferation and, correspondingly, a reduction in the serum prostate specific antigen (PSA) level. AR over-expression in prostate cancer represents a key mechanism associated with prostate cancer hormone resistance. |
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| has database cross reference | ||
| label |
enzalutamide |
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| NCI Thesaurus ID | ||
| prefixIRI |
CHEBI:68534 |
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| prefLabel |
enzalutamide |
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| RxNorm ID | ||
| SNOMED CT Identifier | ||
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_50492 http://purl.obolibrary.org/obo/CHEBI_22702 http://purl.obolibrary.org/obo/CHEBI_83565 |