Link to this page
Gender, Sex, and Sexual Orientation Ontology
| Preferred Name | enzalutamide | |
| Synonyms |
|
|
| Definitions |
A benzamide obtained by formal condensation of the carboxy group of 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl}-2-fluorobenzoic acid with methylamine. Used for the treatment of of metastatic castration-resistant prostate cancer. An orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. Through a mechanism that is reported to be different from other approved AR antagonists, enzalutamide inhibits the activity of prostate cancer cell ARs, which may result in a reduction in prostate cancer cell proliferation and, correspondingly, a reduction in the serum prostate specific antigen (PSA) level. AR over-expression in prostate cancer represents a key mechanism associated with prostate cancer hormone resistance. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_68534 |
|
| ATC Code |
L02BB04
|
|
| ChEBI ID | ||
| definition |
A benzamide obtained by formal condensation of the carboxy group of 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl}-2-fluorobenzoic acid with methylamine. Used for the treatment of of metastatic castration-resistant prostate cancer. An orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. Through a mechanism that is reported to be different from other approved AR antagonists, enzalutamide inhibits the activity of prostate cancer cell ARs, which may result in a reduction in prostate cancer cell proliferation and, correspondingly, a reduction in the serum prostate specific antigen (PSA) level. AR over-expression in prostate cancer represents a key mechanism associated with prostate cancer hormone resistance.
|
|
| has database cross reference | ||
| label |
enzalutamide
|
|
| NCI Thesaurus ID | ||
| prefixIRI |
CHEBI:68534
|
|
| prefLabel |
enzalutamide
|
|
| RxNorm ID | ||
| SNOMED CT Identifier | ||
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_50492 http://purl.obolibrary.org/obo/CHEBI_22702 http://purl.obolibrary.org/obo/CHEBI_83565 |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |