loading...| Preferred Name | flutamide | |
| Synonyms |
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| Definitions |
A toluidine derivative and a nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_5132 |
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| ATC Code |
L02BB01 |
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| ChEBI ID | ||
| definition |
A toluidine derivative and a nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. |
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| has database cross reference | ||
| label |
flutamide |
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| MeSH Descriptor ID | ||
| NCI Thesaurus ID | ||
| prefixIRI |
CHEBI:5132 |
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| prefLabel |
flutamide |
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| RxNorm ID | ||
| SNOMED CT Identifier | ||
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