loading...| Preferred Name |
paraneoplastic syndrome |
|
| Synonyms |
paraneoplastic syndrome |
|
| Definitions |
A classification for rare disorders of diverse organ systems (endocrine, neuromuscular, gastrointestinal, renal, dermatologic, rheumatologic, hematologic) that are affected by substances secreted by a distant neoplasm but not by the action of the neoplasm itself metastasizing to that organ or tissue. Less than 1 % of neoplasms are associated with these syndromes. An immune-mediated response to neoplasm-elaborated proteins may be the cause of these syndromes. Additionally, their manifestation may signal the presence of an occult neoplasm, potentially at an earlier stage of disease thereby leading to a better clinical outcome. Constitutional signs may include fever, night sweats, anorexia and cachexia. Clinical course is usually progressive. Prognosis is variable depending on the effective treatment of the underlying neoplasm. |
|
| ID |
http://purl.obolibrary.org/obo/MONDO_0021073 |
|
| exactMatch |
http://identifiers.org/snomedct/49783001 http://identifiers.org/mesh/D010257 |
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| hasDbXref |
SCTID:49783001 UMLS:C0030472 MESH:D010257 NCIT:C3311 |
|
| hasExactSynonym |
paraneoplastic syndrome |
|
| IAO_0000115 |
A classification for rare disorders of diverse organ systems (endocrine, neuromuscular, gastrointestinal, renal, dermatologic, rheumatologic, hematologic) that are affected by substances secreted by a distant neoplasm but not by the action of the neoplasm itself metastasizing to that organ or tissue. Less than 1 % of neoplasms are associated with these syndromes. An immune-mediated response to neoplasm-elaborated proteins may be the cause of these syndromes. Additionally, their manifestation may signal the presence of an occult neoplasm, potentially at an earlier stage of disease thereby leading to a better clinical outcome. Constitutional signs may include fever, night sweats, anorexia and cachexia. Clinical course is usually progressive. Prognosis is variable depending on the effective treatment of the underlying neoplasm. |
|
| id |
MONDO:0021073 |
|
| label |
paraneoplastic syndrome |
|
| notation |
MONDO:0021073 |
|
| prefLabel |
paraneoplastic syndrome |
|
| subClassOf |