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Experimental Factor Ontology
| Preferred Name | Hepatic steatosis | |
| Synonyms |
Fatty liver Liver steatosis Fatty infiltration of liver Steatosis |
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| Definitions |
Steatosis is a term used to denote lipid accumulation within hepatocytes. Although steatosis is the hallmark of the fatty liver disease, it is not a specific feature because it can be seen as part of other disease processes, such as drug injury, Wilson disease, or hepatitis C virus infection (especially genotype-3). Involvement of less than 5% of the hepatocytes by steatosis is considered clinically insignificant and within reference range. Based on the morphologic appearance and the size of the lipid droplets within the cytoplasm of the hepatocytes, steatosis is characterized as macrovesicular or microvesicular. Macrovesicular steatosis is characterized by large lipid droplets occupying the cytoplasm, displacing the nucleus to the periphery (large droplet macrovesicular steatosis) or multiple small lipid droplets of variable size occupying the cytoplasm with the nucleus maintaining its central location (small droplet macrovesicular steatosis). Microvesicular steatosis is characterized by innumerable tiny, relatively uniform lipid vacuoles that result in a bubbly appearance of the hepatocytes. |
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| ID |
http://purl.obolibrary.org/obo/HP_0001397 |
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| comment |
Although steatosis is the hallmark of the fatty liver disease, it is not a specific feature because it can be seen as part of other disease processes, such as drug injury, Wilson disease, or hepatitis C virus infection (especially genotype-3). Involvement of less than 5% of the hepatocytes by steatosis is considered clinically insignificant and within reference range. Based on the morphologic appearance and the size of the lipid droplets within the cytoplasm of the hepatocytes, steatosis is characterized as macrovesicular or microvesicular. Macrovesicular steatosis is characterized by large lipid droplets occupying the cytoplasm, displacing the nucleus to the periphery (large droplet macrovesicular steatosis) or multiple small lipid droplets of variable size occupying the cytoplasm with the nucleus maintaining its central location (small droplet macrovesicular steatosis). Microvesicular steatosis is characterized by innumerable tiny, relatively uniform lipid vacuoles that result in a bubbly appearance of the hepatocytes.
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| database_cross_reference |
SNOMEDCT_US:442191002 SNOMEDCT_US:197321007 SNOMEDCT:197321007 UMLS:C2711227 OMIM:228100 SNOMEDCT:442191002
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| definition |
Steatosis is a term used to denote lipid accumulation within hepatocytes.
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| gwas_trait |
true
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| has_alternative_id |
HP:0002252 HP:0200121
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| has_exact_synonym |
Fatty liver Liver steatosis Fatty infiltration of liver Steatosis
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| id |
HP:0001397
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| label |
Hepatic steatosis
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| notation |
HP:0001397
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| preferred label |
Hepatic steatosis
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| prefLabel |
Hepatic steatosis
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| subClassOf |
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