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The Drug Ontology
| Preferred Name | paromomycin | |
| Synonyms |
Hydroxymycin paromomycine paromomicina Zygomycin A1 paromomycin Paromomycin I aminosidine hydroxymycin paromomycinum Monomycin A (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside paucimycinum crestomycin Aminosidin Catenulin Neomycin E R 400 R-400 estomycin neomycin E paucimycin PAROMOMYCIN Paromomycin |
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| Definitions |
An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_7934 |
|
| alternative label |
Hydroxymycin paromomycine paromomicina Zygomycin A1 paromomycin Paromomycin I aminosidine hydroxymycin paromomycinum Monomycin A (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside paucimycinum crestomycin Aminosidin Catenulin Neomycin E R 400 R-400 estomycin neomycin E paucimycin PAROMOMYCIN Paromomycin
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|
| charge |
0
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|
| database_cross_reference |
Drug_Central:2067 Patent:US2916485 PMID:18947845 KEGG:C00832 DrugBank:DB01421 CAS:7542-37-2 PMID:8036682 Patent:US2895876 KEGG:D07467 PDBeChem:PAR PMID:18447603 Reaxys:72285
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|
| definition |
An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis.
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|
| formula |
C23H45N5O14
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|
| has characteristic |
http://purl.obolibrary.org/obo/CHEBI_35820 |
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| has functional parent | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_35820 |
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| has_alternative_id |
CHEBI:44703
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|
| has_exact_synonym |
PAROMOMYCIN Paromomycin (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside
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|
| has_obo_namespace |
chebi_ontology
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| has_related_synonym |
Hydroxymycin paromomycine paromomicina Zygomycin A1 paromomycin Paromomycin I aminosidine hydroxymycin paromomycinum Monomycin A (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside paucimycinum crestomycin Aminosidin Catenulin Neomycin E R 400 R-400 estomycin neomycin E paucimycin
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|
| has_RxCUI |
7934
|
|
| id |
CHEBI:7934
|
|
| in_subset | ||
| inchi |
InChI=1S/C23H45N5O14/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22/h5-23,29-36H,1-4,24-28H2/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
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|
| inchikey |
UOZODPSAJZTQNH-LSWIJEOBSA-N
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|
| label |
paromomycin
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|
| mass |
615.62850
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|
| monoisotopicmass |
615.29630
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|
| notation |
CHEBI:7934
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|
| prefLabel |
paromomycin
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|
| smiles |
NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O
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| subClassOf |
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