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The Drug Ontology
| Preferred Name | oxyphenbutazone | |
| Synonyms |
p-Hydroxyphenylbutazone Oxyphenylbutazone Oxi-fenibutol 3,5-Dioxo-1-phenyl-2-(p-hydroxyphenyl)-4-N-butylpyrazolidene 4-Butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione 1-(p-Hydroxyphenyl)-2-phenyl-4-butyl-3,5-pyrazolidinedione Oxiphenbutazonum 4-Butyl-2-(p-hydroxyphenyl)-1-phenyl-3,5-pyrazolidinedione 4-Butyl-2-(4-hydroxyphenyl)-1-phenyl-3,5-dioxopyrazolidine Oxifenylbutazon oxyphenbutazonum 1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-butylpyrazolidine oxifenbutazona 4-Butyl-1-(p-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione oxyphenbutazone 1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-n-butylpyrazolidine p-Oxyphenylbutazone Hydroxyphenylbutazon |
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| Definitions |
A metabolite of phenylbutazone obtained by hydroxylation at position 4 of one of the phenyl rings. Commonly used (as its hydrate) to treat pain, swelling and stiffness associated with arthritis and gout, it was withdrawn from the market 1984 following association with blood dyscrasis and Stevens-Johnson syndrome. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_76258 |
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| alternative label |
p-Hydroxyphenylbutazone Oxyphenylbutazone Oxi-fenibutol 3,5-Dioxo-1-phenyl-2-(p-hydroxyphenyl)-4-N-butylpyrazolidene 4-Butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione 1-(p-Hydroxyphenyl)-2-phenyl-4-butyl-3,5-pyrazolidinedione Oxiphenbutazonum 4-Butyl-2-(p-hydroxyphenyl)-1-phenyl-3,5-pyrazolidinedione 4-Butyl-2-(4-hydroxyphenyl)-1-phenyl-3,5-dioxopyrazolidine Oxifenylbutazon oxyphenbutazonum 1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-butylpyrazolidine oxifenbutazona 4-Butyl-1-(p-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione oxyphenbutazone 1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-n-butylpyrazolidine p-Oxyphenylbutazone Hydroxyphenylbutazon
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|
| charge |
0
|
|
| database_cross_reference |
Patent:US2008014272 Drug_Central:2036 PMID:14345781 PMID:766157 PMID:6860567 DrugBank:DB03585 PMID:1222682 LINCS:LSM-5029 PMID:18963985 PMID:23012453 PMID:19161668 PMID:23983013 PMID:546857 PMID:20299217 Patent:WO2005107748 Patent:EP642336 PMID:501546 PMID:21428758 CAS:129-20-4 Reaxys:307474 PMID:141661 PMID:380595 PMID:2862290 PMID:6617711 PMID:7001487 PMID:7309664 KEGG:C19494 PMID:835859 Wikipedia:Oxyphenbutazone PMID:7368966 PMID:6894379 KEGG:D08324
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|
| definition |
A metabolite of phenylbutazone obtained by hydroxylation at position 4 of one of the phenyl rings. Commonly used (as its hydrate) to treat pain, swelling and stiffness associated with arthritis and gout, it was withdrawn from the market 1984 following association with blood dyscrasis and Stevens-Johnson syndrome.
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|
| formula |
C19H20N2O3
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|
| has characteristic |
http://purl.obolibrary.org/obo/CHEBI_35610 http://purl.obolibrary.org/obo/CHEBI_35493 http://purl.obolibrary.org/obo/CHEBI_35845 http://purl.obolibrary.org/obo/CHEBI_49103 http://purl.obolibrary.org/obo/CHEBI_33281 |
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| has functional parent | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_35610 http://purl.obolibrary.org/obo/CHEBI_35493 http://purl.obolibrary.org/obo/CHEBI_35845 http://purl.obolibrary.org/obo/CHEBI_49103 http://purl.obolibrary.org/obo/CHEBI_33281 |
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| has_obo_namespace |
chebi_ontology
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|
| has_related_synonym |
p-Hydroxyphenylbutazone Oxyphenylbutazone Oxi-fenibutol 3,5-Dioxo-1-phenyl-2-(p-hydroxyphenyl)-4-N-butylpyrazolidene 4-Butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione 1-(p-Hydroxyphenyl)-2-phenyl-4-butyl-3,5-pyrazolidinedione Oxiphenbutazonum 4-Butyl-2-(p-hydroxyphenyl)-1-phenyl-3,5-pyrazolidinedione 4-Butyl-2-(4-hydroxyphenyl)-1-phenyl-3,5-dioxopyrazolidine Oxifenylbutazon oxyphenbutazonum 1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-butylpyrazolidine oxifenbutazona 4-Butyl-1-(p-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione oxyphenbutazone 1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-n-butylpyrazolidine p-Oxyphenylbutazone Hydroxyphenylbutazon
|
|
| has_RxCUI |
7816
|
|
| id |
CHEBI:76258
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|
| in_subset | ||
| inchi |
InChI=1S/C19H20N2O3/c1-2-3-9-17-18(23)20(14-7-5-4-6-8-14)21(19(17)24)15-10-12-16(22)13-11-15/h4-8,10-13,17,22H,2-3,9H2,1H3
|
|
| inchikey |
HFHZKZSRXITVMK-UHFFFAOYSA-N
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|
| label |
oxyphenbutazone
|
|
| mass |
324.37370
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|
| monoisotopicmass |
324.14739
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|
| notation |
CHEBI:76258
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|
| prefLabel |
oxyphenbutazone
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|
| smiles |
CCCCC1C(=O)N(N(C1=O)c1ccc(O)cc1)c1ccccc1
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| subClassOf |
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