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The Drug Ontology
Last uploaded:
December 20, 2024
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| Preferred Name | nelarabine | |
| Synonyms |
nelzarabine Nelzarabine 2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine Arranon 9-(beta-D-arabinofuranosyl)-6-methoxy-9H-purin-2-amine |
|
| Definitions |
A purine nucleoside in which O-methylguanine is attached to arabinofuranose via a beta-N(9)-glycosidic bond. Inhibits DNA synthesis and causes cell death; a prodrug of 9-beta-D-arabinofuranosylguanine (ara-G). |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_63612 |
|
| alternative label |
nelzarabine Nelzarabine 2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine Arranon 9-(beta-D-arabinofuranosyl)-6-methoxy-9H-purin-2-amine
|
|
| charge |
0
|
|
| database_cross_reference |
PMID:21715318 PMID:21320002 KEGG:D06488 CAS:121032-29-9 PMID:21151585 PMID:20043113 KEGG:D05134 PMID:22184539 PMID:18586926 PMID:21353591 PMID:20528871 PMID:21737993 PMID:21190039 Drug_Central:1892 PMID:20616909 DrugBank:DB01280 PMID:19825456 PMID:21730354 Reaxys:13568768 PMID:20796200 PMID:63612
|
|
| definition |
A purine nucleoside in which O-methylguanine is attached to arabinofuranose via a beta-N(9)-glycosidic bond. Inhibits DNA synthesis and causes cell death; a prodrug of 9-beta-D-arabinofuranosylguanine (ara-G).
|
|
| formula |
C11H15N5O5
|
|
| has characteristic |
http://purl.obolibrary.org/obo/CHEBI_35610 |
|
| has functional parent | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_35610 |
|
| has_exact_synonym |
9-(beta-D-arabinofuranosyl)-6-methoxy-9H-purin-2-amine
|
|
| has_obo_namespace |
chebi_ontology
|
|
| has_related_synonym |
nelzarabine Nelzarabine 2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine Arranon
|
|
| has_RxCUI |
274771
|
|
| id |
CHEBI:63612
|
|
| in_subset | ||
| inchi |
InChI=1S/C11H15N5O5/c1-20-9-5-8(14-11(12)15-9)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7+,10-/m1/s1
|
|
| inchikey |
IXOXBSCIXZEQEQ-UHTZMRCNSA-N
|
|
| label |
nelarabine
|
|
| mass |
297.26730
|
|
| monoisotopicmass |
297.10732
|
|
| notation |
CHEBI:63612
|
|
| prefLabel |
nelarabine
|
|
| smiles |
COc1nc(N)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O
|
|
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_26394 |
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