loading...| Preferred Name | suramin | |
| Synonyms |
8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID Belganyl Naganol Naphuride 8,8'-{carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]}dinaphthalene-1,3,5-trisulfonic acid Suramin |
|
| Definitions |
A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_45906 |
|
| alternative label |
8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID Belganyl Naganol Naphuride 8,8'-{carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]}dinaphthalene-1,3,5-trisulfonic acid Suramin |
|
| charge |
0 |
|
| database_cross_reference |
PMID:29414872 KEGG:C07974 PMID:28457855 PMID:30449075 PMID:11549724 PDBeChem:SVR PMID:30771091 Beilstein:8185304 PMID:31844000 PMID:31409229 PMID:7947391 PMID:15774519 DrugBank:DB04786 Beilstein:3230873 PMID:8769855 PMID:15733555 Chemspider:5168 PMID:30543088 PMID:30393012 CAS:145-63-1 LINCS:LSM-5775 HMDB:HMDB0015582 AGR:IND606744035 Wikipedia:Suramin PMID:30172846 PMID:30528604 PMID:31803569 PMID:31667504 PMID:31346035 PMID:31727005 Drug_Central:2966 |
|
| definition |
A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years. |
|
| formula |
C51H40N6O23S6 |
|
| has functional parent | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_35610 http://purl.obolibrary.org/obo/CHEBI_38999 http://purl.obolibrary.org/obo/CHEBI_37700 http://purl.obolibrary.org/obo/CHEBI_91079 http://purl.obolibrary.org/obo/CHEBI_35444 http://purl.obolibrary.org/obo/CHEBI_68494 http://purl.obolibrary.org/obo/CHEBI_65259 http://purl.obolibrary.org/obo/CHEBI_67114 |
|
| has_alternative_id |
CHEBI:45904 CHEBI:9363 |
|
| has_exact_synonym |
8,8'-{carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]}dinaphthalene-1,3,5-trisulfonic acid Suramin |
|
| has_obo_namespace |
chebi_ontology |
|
| has_related_synonym |
8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID Belganyl Naganol Naphuride |
|
| has_RxCUI |
10256 |
|
| id |
CHEBI:45906 |
|
| in_subset | ||
| inchi |
InChI=1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80) |
|
| inchikey |
FIAFUQMPZJWCLV-UHFFFAOYSA-N |
|
| is conjugate acid of | ||
| label |
suramin |
|
| mass |
1297.260 |
|
| monoisotopicmass |
1296.04691 |
|
| notation |
CHEBI:45906 |
|
| prefLabel |
suramin |
|
| smiles |
C12=C(C=C(C=C1C(=CC=C2NC(C3=CC=C(C(NC(C=4C=CC=C(NC(NC5=CC=CC(C(NC=6C(=CC=C(C(NC=7C8=C(C=C(C=C8C(=CC7)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O)=O)C6)C)=O)=C5)=O)C4)=O)=C3)C)=O)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O |
|
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_36336 |