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The Drug Ontology
| Preferred Name | dapsone | |
| Synonyms |
Bis(p-aminophenyl) sulfone 4-(4-aminophenylsulfonyl)aniline p-aminophenyl sulfone 4,4'-dapsone bis(4-aminophenyl)sulfone p,p-sulphonylbisbenzamine 4,4'-sulfonylbisaniline Diaphenylsulfone 4-(4-amino-benzenesulfonyl)-phenylamine 4,4'-diaminodiphenyl sulfone p,p'-diaminodiphenyl sulfone p,p-sulphonylbisbenzenamine 4-aminophenyl sulfone DIAPHENYLSULFONE 4,4'-Sulfonylbisbenzenamine 1,1'-sulfonylbis(4-aminobenzene) 4-(4-aminophenylsulfonyl)benzenamine DADPS DDS dapsona dapsone dapsonum 4,4'-sulfonyldianiline DAPSONE Dapsone |
|
| Definitions |
A sulfone that is diphenylsulfone in which the hydrogen atom at the 4 position of each of the phenyl groups is substituted by an amino group. It is active against a wide range of bacteria, but is mainly employed for its actions against Mycobacterium leprae, being used as part of multidrug regimens in the treatment of all forms of leprosy. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_4325 |
|
| alternative label |
Bis(p-aminophenyl) sulfone 4-(4-aminophenylsulfonyl)aniline p-aminophenyl sulfone 4,4'-dapsone bis(4-aminophenyl)sulfone p,p-sulphonylbisbenzamine 4,4'-sulfonylbisaniline Diaphenylsulfone 4-(4-amino-benzenesulfonyl)-phenylamine 4,4'-diaminodiphenyl sulfone p,p'-diaminodiphenyl sulfone p,p-sulphonylbisbenzenamine 4-aminophenyl sulfone DIAPHENYLSULFONE 4,4'-Sulfonylbisbenzenamine 1,1'-sulfonylbis(4-aminobenzene) 4-(4-aminophenylsulfonyl)benzenamine DADPS DDS dapsona dapsone dapsonum 4,4'-sulfonyldianiline DAPSONE Dapsone
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|
| charge |
0
|
|
| database_cross_reference |
PMID:24232126 Reaxys:788055 DrugBank:DB00250 HMDB:HMDB0014395 PMID:24512442 PMID:28732451 PMID:29280553 PMID:29233746 PMID:29045131 PMID:28434260 PMID:28699887 PMID:16361748 CAS:80-08-0 Patent:FR829926 PMID:18035772 PMID:29192999 Drug_Central:782 LINCS:LSM-5714 PMID:29192974 KEGG:D00592 Wikipedia:Dapsone KEGG:C07666
|
|
| definition |
A sulfone that is diphenylsulfone in which the hydrogen atom at the 4 position of each of the phenyl groups is substituted by an amino group. It is active against a wide range of bacteria, but is mainly employed for its actions against Mycobacterium leprae, being used as part of multidrug regimens in the treatment of all forms of leprosy.
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|
| formula |
C12H12N2O2S
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|
| has characteristic |
http://purl.obolibrary.org/obo/CHEBI_35472 |
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| has functional parent | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_35472 |
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| has_alternative_id |
CHEBI:226356
|
|
| has_exact_synonym |
4,4'-sulfonyldianiline DAPSONE Dapsone
|
|
| has_obo_namespace |
chebi_ontology
|
|
| has_related_synonym |
Bis(p-aminophenyl) sulfone 4-(4-aminophenylsulfonyl)aniline p-aminophenyl sulfone 4,4'-dapsone bis(4-aminophenyl)sulfone p,p-sulphonylbisbenzamine 4,4'-sulfonylbisaniline Diaphenylsulfone 4-(4-amino-benzenesulfonyl)-phenylamine 4,4'-diaminodiphenyl sulfone p,p'-diaminodiphenyl sulfone p,p-sulphonylbisbenzenamine 4-aminophenyl sulfone DIAPHENYLSULFONE 4,4'-Sulfonylbisbenzenamine 1,1'-sulfonylbis(4-aminobenzene) 4-(4-aminophenylsulfonyl)benzenamine DADPS DDS dapsona dapsone dapsonum
|
|
| has_RxCUI |
3108
|
|
| id |
CHEBI:4325
|
|
| in_subset | ||
| inchi |
InChI=1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2
|
|
| inchikey |
MQJKPEGWNLWLTK-UHFFFAOYSA-N
|
|
| label |
dapsone
|
|
| mass |
248.30100
|
|
| monoisotopicmass |
248.06195
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|
| notation |
CHEBI:4325
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|
| prefLabel |
dapsone
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|
| smiles |
Nc1ccc(cc1)S(=O)(=O)c1ccc(N)cc1
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| subClassOf |
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