The Drug Ontology

Last uploaded: December 20, 2024
Preferred Name

pitavastatin
Synonyms

pitavastatinum

pitavastatia

pitavastatin

pitavastatine

NK 104

NK-104

(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid

Definitions

A dihydroxy monocarboxylic acid that is (6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]hept-6-enoic acid in which the two hydroxy groups are located at positions 3 and 5 (the 3R,5S-stereoisomer). Used as its calcium salt for treatment of hypercholesterolemia (elevated levels of cholesterol in the blood) on patients unable to sufficiently lower their cholesterol levels by diet and exercise.

ID

http://purl.obolibrary.org/obo/CHEBI_32020

alternative label

pitavastatinum

pitavastatia

pitavastatin

pitavastatine

NK 104

NK-104

(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid

charge

0

database_cross_reference

Patent:US2011269962

HMDB:HMDB0041991

Patent:EP2141155

PMID:22410289

PMID:22332608

PMID:22268518

PMID:22149769

Patent:US2012016129

PMID:22948417

PMID:22053916

Reaxys:7257773

CAS:147511-69-1

PMID:22679249

PMID:21075465

PMID:22807641

PMID:23007012

PMID:21884024

PMID:22878405

PMID:22520230

PMID:22472908

PMID:21585411

PMID:22133277

PMID:22356292

KEGG:C13334

PMID:22361916

PMID:22627182

PMID:22345687

Wikipedia:Pitavastatin

PMID:22884685

PMID:22077103

Drug_Central:2214

PMID:22850760

PMID:23161429

definition

A dihydroxy monocarboxylic acid that is (6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]hept-6-enoic acid in which the two hydroxy groups are located at positions 3 and 5 (the 3R,5S-stereoisomer). Used as its calcium salt for treatment of hypercholesterolemia (elevated levels of cholesterol in the blood) on patients unable to sufficiently lower their cholesterol levels by diet and exercise.

formula

C25H24FNO4

has characteristic

http://purl.obolibrary.org/obo/CHEBI_22586

has role

http://purl.obolibrary.org/obo/CHEBI_22586

has_exact_synonym

(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid

has_obo_namespace

chebi_ontology

has_related_synonym

pitavastatinum

pitavastatia

pitavastatin

pitavastatine

NK 104

NK-104

has_RxCUI

861634

id

CHEBI:32020

in_subset

http://purl.obolibrary.org/obo/chebi#3_STAR

inchi

InChI=1S/C25H24FNO4/c26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31/h1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31)/b12-11+/t18-,19-/m1/s1

inchikey

VGYFMXBACGZSIL-MCBHFWOFSA-N

is conjugate acid of

http://purl.obolibrary.org/obo/CHEBI_71260

label

pitavastatin

mass

421.46080

monoisotopicmass

421.16894

notation

CHEBI:32020

prefLabel

pitavastatin

smiles

O[C@H](C[C@H](O)\C=C\c1c(nc2ccccc2c1-c1ccc(F)cc1)C1CC1)CC(O)=O

subClassOf

http://purl.obolibrary.org/obo/CHEBI_51454

http://purl.obolibrary.org/obo/CHEBI_87635

http://purl.obolibrary.org/obo/CHEBI_26513

http://purl.obolibrary.org/obo/CHEBI_83575

http://purl.obolibrary.org/obo/CHEBI_35972

Delete Subject Author Type Created
No notes to display
Create mapping

Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_32020 PDRO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_32020 DINTO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_32020 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_32020 BERO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_32020 DDSS SAME_URI
http://purl.bioontology.org/ontology/SNOMEDCT/443586000 SNOMEDCT LOOM
http://www.phoc.org.cn/pmo/class/PMO_00025448 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/NDDF/013206 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C108475 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907003401043739 IOBC LOOM
http://purl.jp/bio/4/id/200906058692132917 IOBC LOOM
http://purl.bioontology.org/ontology/ATC/C10AA08 ATC LOOM
http://purl.bioontology.org/ontology/MESH/C108475 MESH LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C87751 NCIT LOOM
http://purl.obolibrary.org/obo/NCIT_C87751 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_32020 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_32020 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_32020 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_32020 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_32020 DDSS LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C1101838 OCHV LOOM
http://www.drugbank.ca/drugs/DB08860 FTC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000180308 NDFRT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#54659 OCHV LOOM
https://go.drugbank.com/drugs/DB08860 MDM LOOM
http://purl.bioontology.org/ontology/VANDF/4029463 VANDF LOOM
http://purl.bioontology.org/ontology/RXNORM/861634 RXNORM LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02125 MIO LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02125 MIO LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02125 MIO LOOM