loading...| Preferred Name |
Marchiafava-Bignami disease |
|
| Synonyms |
acute Marchiafava-Bignami disease chronic Marchiafava-Bignami syndrome MBD metabolic bone disease metabolic bone disorder Marchiafava Bignami disease |
|
| Definitions |
Marchiafava Bignami disease is defined by characteristic demyelination of the corpus callosum (erosion of the protective covering of nerve fibers joining the 2 hemispheres of the brain). The disease seems to most often affect severe and chronic alcoholics in their middle or late adult life. Early symptoms may include depression, paranoia, psychosis, or dementia. Seizures are common, and hemiparesis, aphasia, abnormal movements, and ataxia may sometimesprogress to coma and/or death. The cause of Marchiafava Bignami disease, including the potential role of nutritional deficiency, remains unknown. Improvement and recovery of some individuals has been reported. Treatment focuses on nutritional support and rehabilitation from alcoholism. |
|
| ID |
http://purl.obolibrary.org/obo/MONDO_0016370 |
|
| altLabel |
acute Marchiafava-Bignami disease chronic Marchiafava-Bignami syndrome MBD metabolic bone disease metabolic bone disorder Marchiafava Bignami disease |
|
| definition |
Marchiafava Bignami disease is defined by characteristic demyelination of the corpus callosum (erosion of the protective covering of nerve fibers joining the 2 hemispheres of the brain). The disease seems to most often affect severe and chronic alcoholics in their middle or late adult life. Early symptoms may include depression, paranoia, psychosis, or dementia. Seizures are common, and hemiparesis, aphasia, abnormal movements, and ataxia may sometimesprogress to coma and/or death. The cause of Marchiafava Bignami disease, including the potential role of nutritional deficiency, remains unknown. Improvement and recovery of some individuals has been reported. Treatment focuses on nutritional support and rehabilitation from alcoholism. |
|
| has characteristic | ||
| has_exact_synonym |
metabolic bone disease metabolic bone disorder Marchiafava Bignami disease |
|
| has_narrow_synonym |
acute Marchiafava-Bignami disease chronic Marchiafava-Bignami syndrome |
|
| has_related_synonym |
MBD |
|
| label |
Marchiafava-Bignami disease |
|
| prefixIRI |
MONDO:0016370 |
|
| prefLabel |
Marchiafava-Bignami disease |
|
| seeAlso |
https://rarediseases.info.nih.gov/diseases/6971/marchiafava-bignami-disease |
|
| textual definition |
Marchiafava Bignami disease is defined by characteristic demyelination of the corpus callosum (erosion of the protective covering of nerve fibers joining the 2 hemispheres of the brain). The disease seems to most often affect severe and chronic alcoholics in their middle or late adult life. Early symptoms may include depression, paranoia, psychosis, or dementia. Seizures are common, and hemiparesis, aphasia, abnormal movements, and ataxia may sometimesprogress to coma and/or death. The cause of Marchiafava Bignami disease, including the potential role of nutritional deficiency, remains unknown. Improvement and recovery of some individuals has been reported. Treatment focuses on nutritional support and rehabilitation from alcoholism. |
|
| subClassOf |