Preferred Name |
perinatal asphyxia |
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Synonyms |
birth depression asphyxia neonatorum perinatal hypoxia birth asphyxia fetal asphyxia intrapartum asphyxia perinatal depression postnatal asphyxia HIE hypoxic-ischemic encephalopathy hypoxia neonatorum asphyxia, in liveborn infant asphyxia - birth perinatal asphyxia hypoxic and ischemic brain injury in the newborn neonatal hypoxic and ischemic brain injury |
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Definitions |
Pathophysiology: There are three stages to brain injury in hypoxic-ischemic encephalopathy. First, there is an immediate primary neuronal injury that occurs due to interruption of oxygen and glucose to the brain. This decreases ATP and results in failure of the ATP-dependent NaK pump. Sodium enters the cell followed by water, causing cell swelling, widespread depolarization, and cell death. Cell death and lysis cause release of glutamate, an excitatory amino acid, which causes an increase in intracellular calcium and further cell death. Following the immediate injury is a latent period of about six hours, during which reperfusion occurs, and some cells recover. Late secondary neuronal injury occurs over the next 24-48 hours as reperfusion results in blood flow to and from damaged areas, spreading toxic neurotransmitters and widening the area of brain affected.[NBK430782] A disorder caused by a lack of blood flow or gas exchange to or from the fetus in the period immediately before, during, or after the birth process. |
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ID |
http://purl.obolibrary.org/obo/MONDO_0006663 |
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comment |
Pathophysiology: There are three stages to brain injury in hypoxic-ischemic encephalopathy. First, there is an immediate primary neuronal injury that occurs due to interruption of oxygen and glucose to the brain. This decreases ATP and results in failure of the ATP-dependent NaK pump. Sodium enters the cell followed by water, causing cell swelling, widespread depolarization, and cell death. Cell death and lysis cause release of glutamate, an excitatory amino acid, which causes an increase in intracellular calcium and further cell death. Following the immediate injury is a latent period of about six hours, during which reperfusion occurs, and some cells recover. Late secondary neuronal injury occurs over the next 24-48 hours as reperfusion results in blood flow to and from damaged areas, spreading toxic neurotransmitters and widening the area of brain affected.[NBK430782] |
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has_exact_synonym |
birth depression asphyxia neonatorum perinatal hypoxia birth asphyxia fetal asphyxia intrapartum asphyxia perinatal depression postnatal asphyxia HIE hypoxic-ischemic encephalopathy hypoxia neonatorum asphyxia, in liveborn infant asphyxia - birth perinatal asphyxia |
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has_related_synonym |
hypoxic and ischemic brain injury in the newborn neonatal hypoxic and ischemic brain injury |
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label |
perinatal asphyxia |
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prefixIRI |
MONDO:0006663 |
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prefLabel |
perinatal asphyxia |
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seeAlso |
https://rarediseases.info.nih.gov/diseases/5857/asphyxia-neonatorum |
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textual definition |
A disorder caused by a lack of blood flow or gas exchange to or from the fetus in the period immediately before, during, or after the birth process. |
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subClassOf |