The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	tetracycline
Synonyms	(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide tetracyclinum C22H24N2O8 Achromycin (4S,4aS,5aS,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide TETRACYCLINE Anhydrotetracycline tetracycline Liquamycin Tsiklomitsin Tetracyclin Tetrazyklin Abramycin Tetracycline Deschlorobiomycin
ID	http://purl.obolibrary.org/obo/CHEBI_27902
AHFScode	52:04.04 08:12.24
altId	CHEBI:9474 CHEBI:45729 CHEBI:26894
ATCCode	J01AA06 G01AA07 J01AA09 S03AA02 S01AA02 J01AA07 D06AA04 S01AA04 D06AA02 S01AA09 A01AB13 D06AA03 S02AA08 J01AA03 A01AB21
CASRN	60-54-8
DBBrand	robitet deschlorobiomycin mericycline sk-tetracycline bristaciclina tsiklomistsin medocycline abricycline abramycin ambramycin sumycin neocycline cytome veracin orlycycline polyotic bristaciclin limecycline solvocin tetra-co biocycline tetrex achromycin democracin dumocyclin tetracycl criseociclina tetramed hostacyclin micycline cyclopar bio-tetra ciclibion panmycin polycycline achromycin v bristacycline tetracycline ii tetracyn resteclin vetacyclinum tetrachel enterocycline copharlan tsiklomitsin tetrafil tetrabon lexacycline cefracycline roviciclina tetradecin agromicina topicycline omegamycin ambramicina retet amycin actisite purocyclina tetraverine
DBname	tetracycline
DBSynonym	tetracycline hcl
Definition	A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.
has effect	http://purl.obolibrary.org/obo/OAE_0000597 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000920 http://purl.obolibrary.org/obo/OAE_0001026 http://purl.obolibrary.org/obo/OAE_0001238 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001234 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0000341 http://purl.obolibrary.org/obo/OAE_0000866 http://purl.obolibrary.org/obo/OAE_0000917 http://purl.obolibrary.org/obo/OAE_0000294 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0001217 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000211 http://purl.obolibrary.org/obo/OAE_0001366 http://purl.obolibrary.org/obo/OAE_0000480
has pharmacological target	http://purl.obolibrary.org/obo/dinto_1426 http://purl.obolibrary.org/obo/dinto_1428 http://purl.obolibrary.org/obo/dinto_2863 http://purl.obolibrary.org/obo/dinto_2953 http://purl.obolibrary.org/obo/dinto_2954 http://purl.obolibrary.org/obo/dinto_3014
has role	http://purl.obolibrary.org/obo/CHEBI_22582 http://purl.obolibrary.org/obo/CHEBI_35820 http://purl.obolibrary.org/obo/CHEBI_48001 http://purl.obolibrary.org/obo/CHEBI_36047
InChI	InChI=1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1
InChIKey	InChIKey=OFVLGDICTFRJMM-WESIUVDSSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_1977 http://purl.obolibrary.org/obo/dinto_1975 http://purl.obolibrary.org/obo/dinto_1426 http://purl.obolibrary.org/obo/dinto_1428 http://purl.obolibrary.org/obo/dinto_2863 http://purl.obolibrary.org/obo/dinto_2953 http://purl.obolibrary.org/obo/dinto_2954 http://purl.obolibrary.org/obo/dinto_4301 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_0343 http://purl.obolibrary.org/obo/dinto_3014 http://purl.obolibrary.org/obo/dinto_0520
is metabolised by	http://purl.obolibrary.org/obo/dinto_0901
label	tetracycline
may interact with	http://purl.obolibrary.org/obo/dinto_DB01401 http://purl.obolibrary.org/obo/CHEBI_7809 http://purl.obolibrary.org/obo/CHEBI_32250 http://purl.obolibrary.org/obo/CHEBI_5098 http://purl.obolibrary.org/obo/dinto_DB01604 http://purl.obolibrary.org/obo/dinto_DB00417 http://purl.obolibrary.org/obo/CHEBI_44185 http://purl.obolibrary.org/obo/CHEBI_5683 http://purl.obolibrary.org/obo/CHEBI_2956 http://purl.obolibrary.org/obo/CHEBI_50859 http://purl.obolibrary.org/obo/CHEBI_4913 http://purl.obolibrary.org/obo/dinto_DB01397 http://purl.obolibrary.org/obo/dinto_DB01294 http://purl.obolibrary.org/obo/CHEBI_575568 http://purl.obolibrary.org/obo/CHEBI_18208 http://purl.obolibrary.org/obo/CHEBI_8713 http://purl.obolibrary.org/obo/dinto_DB00893 http://purl.obolibrary.org/obo/CHEBI_3393 http://purl.obolibrary.org/obo/CHEBI_161680 http://purl.obolibrary.org/obo/CHEBI_53766 http://purl.obolibrary.org/obo/dinto_DB00258 http://purl.obolibrary.org/obo/dinto_DB01370 http://purl.obolibrary.org/obo/CHEBI_50173 http://purl.obolibrary.org/obo/CHEBI_133809 http://purl.obolibrary.org/obo/CHEBI_28971 http://purl.obolibrary.org/obo/dinto_DB01574 http://purl.obolibrary.org/obo/CHEBI_48947 http://purl.obolibrary.org/obo/dinto_DB01357 http://purl.obolibrary.org/obo/CHEBI_59594 http://purl.obolibrary.org/obo/CHEBI_9654 http://purl.obolibrary.org/obo/dinto_DB01375 http://purl.obolibrary.org/obo/dinto_DB01593 http://purl.obolibrary.org/obo/CHEBI_15367 http://purl.obolibrary.org/obo/CHEBI_6919 http://purl.obolibrary.org/obo/dinto_DB01378 http://purl.obolibrary.org/obo/CHEBI_9622 http://purl.obolibrary.org/obo/CHEBI_9398 http://purl.obolibrary.org/obo/CHEBI_10033 http://purl.obolibrary.org/obo/CHEBI_9587 http://purl.obolibrary.org/obo/CHEBI_49566 http://purl.obolibrary.org/obo/dinto_DB01606 http://purl.obolibrary.org/obo/dinto_DB01164 http://purl.obolibrary.org/obo/CHEBI_7447 http://purl.obolibrary.org/obo/CHEBI_31444 http://purl.obolibrary.org/obo/dinto_DB00977 http://purl.obolibrary.org/obo/CHEBI_4513 http://purl.obolibrary.org/obo/CHEBI_4511 http://purl.obolibrary.org/obo/CHEBI_6067 http://purl.obolibrary.org/obo/dinto_DB01373 http://purl.obolibrary.org/obo/dinto_DB01028 http://purl.obolibrary.org/obo/dinto_DB01592 http://purl.obolibrary.org/obo/CHEBI_8232 http://purl.obolibrary.org/obo/dinto_DB02443 http://purl.obolibrary.org/obo/CHEBI_2968 http://purl.obolibrary.org/obo/CHEBI_51210 http://purl.obolibrary.org/obo/CHEBI_2676
prefixIRI	obo2:CHEBI_27902
prefLabel	tetracycline
related with	http://purl.obolibrary.org/obo/dinto_0217
SMILES	[H][C@@]12C[C@@]3([H])C(=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C)C(=O)C1=C(O)C=CC=C1[C@@]3(C)O [H][C@@]12C[C@@]3([H])C(C(=O)c4c(O)cccc4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C
Synonym	(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide tetracyclinum C22H24N2O8 Achromycin (4S,4aS,5aS,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide TETRACYCLINE Anhydrotetracycline tetracycline Liquamycin Tsiklomitsin Tetracyclin Tetrazyklin Abramycin Tetracycline Deschlorobiomycin
xref	CiteXplore:18326855 KEGG DRUG:D00201 Reaxys:2230417 Patent:US3005023 CiteXplore:18406588 CiteXplore:16443056 CiteXplore:11744940 Patent:US3301899 ChEMBL:473985 CiteXplore:15913752 CASRN:60-54-8 RxList:http://www.rxlist.com/cgi/generic2/tetcycl2.htm CiteXplore:19112759 ChEBI:27902 CiteXplore:17251127 Beilstein:2230417 CiteXplore:14585720 PubChem Compound:5280962 CiteXplore:11550419 PubChem Substance:46506693 PDBeChem:TAC ChemSpider:4510286 DrugBank:DB00759 CiteXplore:16749547 MetaCyc:CPD0-1414 KEGG COMPOUND:C06570 Patent:US2699054 PDB:ATC CiteXplore:17260506 CiteXplore:12934399 Drugs Product Database (DPD):527777 CiteXplore:15825421 Wikipedia:Tetracycline Patent:US2886595 CiteXplore:19136803 CiteXplore:1650428 Wikipedia:http://en.wikipedia.org/wiki/Tetracycline Gmelin:1103368 National Drug Code Directory:0172-2416-60 CiteXplore:19032078 Patent:US3019173 CiteXplore:11061623 Drugs.com:http://www.drugs.com/tetracycline.html Patent:US2712517 PharmGKB:PA451640
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_27902	GO-PLUS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27902	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27902	FYPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27902	HOIP	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27902	PHIPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27902	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27902	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27902	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27902	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27902	TXPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27902	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27902	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27902	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27902	KTAO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27902	MCO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27902	MAXO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27902	GO-PLUS	LOOM
http://purl.obolibrary.org/obo/XCO_0001235	XCO	LOOM
http://purl.obolibrary.org/obo/CHEBI_27902	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_27902	FYPO	LOOM
https://github.com/sap218/ocimido/blob/master/ontology/ocimido.owl#OCIMIDO_00586	OCIMIDO	LOOM
http://purl.bioontology.org/ontology/CSP/0209-5887	CRISP	LOOM
http://purl.bioontology.org/ontology/LNC/LP16286-4	LOINC	LOOM
http://www.projecthalo.com/aura#Tetracycline	AURA	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.847.562.900.875	RH-MESH	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146005	NDFRT	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C865	NCIT	LOOM
http://purl.bioontology.org/ontology/RCD/x02Lq	RCD	LOOM
https://go.drugbank.com/drugs/DB00759	MDM	LOOM
http://purl.bioontology.org/ontology/ATC/S03AA02	ATC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0039651	OCHV	LOOM
http://www.co-ode.org/ontologies/galen#Tetracycline	GALEN	LOOM
http://www.gamuts.net/entity#tetracycline	GAMUTS	LOOM
http://purl.bioontology.org/ontology/ATC/A01AB13	ATC	LOOM
http://purl.bioontology.org/ontology/NDDF/002738	NDDF	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#12132	OCHV	LOOM
http://purl.bioontology.org/ontology/RXNORM/10395	RXNORM	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016925	PMAPP-PMO	LOOM
http://purl.jp/bio/4/id/200906031053631281	IOBC	LOOM
http://www.bioassayontology.org/bao#BAO_0000748	BAO	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU008490	LOINC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.615.562.900.875	RH-MESH	LOOM
http://purl.bioontology.org/ontology/MESH/D013752	MESH	LOOM
http://stirdf.jst.go.jp/id/200907079283121416	IOBC	LOOM
http://purl.obolibrary.org/obo/OMIT_0014606	OMIT	LOOM
http://www.drugbank.ca/drugs/DB00759	FTC	LOOM
http://purl.obolibrary.org/obo/NCIT_C865	BERO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0039644	OCHV	LOOM
http://purl.obolibrary.org/obo/ARO_0000051	ARO	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372809001	SNOMEDCT	LOOM
http://purl.obolibrary.org/obo/CHEBI_27902	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_27902	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_27902	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_27902	TXPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_27902	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_27902	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_27902	NIFSTD	LOOM
http://purl.obolibrary.org/obo/CHEBI_27902	KTAO	LOOM
http://purl.obolibrary.org/obo/CHEBI_27902	MCO	LOOM
http://purl.obolibrary.org/obo/CHEBI_27902	MAXO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D013752	RH-MESH	LOOM
http://purl.bioontology.org/ontology/ATC/J01AA07	ATC	LOOM
http://purl.bioontology.org/ontology/ATC/S02AA08	ATC	LOOM
http://purl.obolibrary.org/obo/MESH_D013752	BERO	LOOM
http://purl.obolibrary.org/obo/IDOMAL_0000228	IDOMAL	LOOM
http://purl.bioontology.org/ontology/ATC/D06AA04	ATC	LOOM
http://purl.bioontology.org/ontology/VANDF/4017625	VANDF	LOOM
http://www.semanticweb.org/ontologies/2010/5/22/Ontology1277229984000.owl#HPI:0000233	HPIO	LOOM
http://purl.bioontology.org/ontology/ATC/S01AA09	ATC	LOOM
http://purl.obolibrary.org/obo/CHEBI_27902	HOIP	LOOM
http://purl.obolibrary.org/obo/CHEBI_27902	PHIPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_27902	CHEBI	LOOM