aminopterin

C19H20N8O5

(2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid

http://purl.obolibrary.org/obo/dinto_DB08878

54-62-6

aminopterine

a-ninopterin

4-amino-4-deoxypteroylglutamate

aminopteridine

4'-amino-folsaeure

n-(4-{[(2,4-diamino-6-pteridinyl)methyl]amino}benzoyl)glutamic acid

pteramina

apga

4-aminofolic acid

minopterin

4-amino-pga

4-aminopteroylglutamic acid

Aminopterin is an amino derivative of folic acid, which was once used as an antineoplastic agent in the treatment of pediatric leukemia. In the 1950 s its production was discontinued in favor of methotrexate, which is less potent but less toxic. Off label, aminopterin has also been used in the treatment of psoriasis. Clinicians need to be aware of the characteristic teratologic effects of aminopterin and methotrexate.

InChI=1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)/t12-/m0/s1

InChIKey=TVZGACDUOSZQKY-LBPRGKRZSA-N

http://purl.obolibrary.org/obo/dinto_1600

aminopterin

obo2:dinto_DB08878

aminopterin

http://purl.obolibrary.org/obo/dinto_1365

NC1=NC2=C(N=C(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=N2)C(N)=N1

C19H20N8O5

(2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid

Wikipedia:http://en.wikipedia.org/wiki/Aminopterin

ChEBI:376180

http://purl.obolibrary.org/obo/dinto_000055