The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	dronedarone
Synonyms	N-[2-butyl-3-({4-[3-(dibutylamino)propoxy]phenyl}carbonyl)-1-benzofuran-5-yl]methanesulfonamide C31H44N2O5S
ID	http://purl.obolibrary.org/obo/dinto_DB04855
AHFScode	24:04.04.20
ATCCode	C01BD07
binds	http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_2149 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_2679 http://purl.obolibrary.org/obo/dinto_2907 http://purl.obolibrary.org/obo/dinto_2962 http://purl.obolibrary.org/obo/dinto_2965 http://purl.obolibrary.org/obo/dinto_3187 http://purl.obolibrary.org/obo/dinto_3475 http://purl.obolibrary.org/obo/dinto_3877 http://purl.obolibrary.org/obo/dinto_2957 http://purl.obolibrary.org/obo/dinto_2959 http://purl.obolibrary.org/obo/dinto_1581 http://purl.obolibrary.org/obo/dinto_2975 http://purl.obolibrary.org/obo/dinto_2979 http://purl.obolibrary.org/obo/dinto_1110 http://purl.obolibrary.org/obo/dinto_1027 http://purl.obolibrary.org/obo/dinto_1135 http://purl.obolibrary.org/obo/dinto_0217 http://purl.obolibrary.org/obo/dinto_4020 http://purl.obolibrary.org/obo/dinto_0234
blocks	http://purl.obolibrary.org/obo/dinto_4020 http://purl.obolibrary.org/obo/dinto_0234
CASRN	141626-36-0
DBBrand	multaq
DBSalt	dronedarone hydrochloride
DBSynonym	sr33589
Definition	Dronedarone is a sinus rhythm controller for management of paroxysmal or persistent atrial fibrillation. Classified as a Class III antiarrhythmic but displays properties of all four Vaughan-Williams classes, dronedarone blocks a multitude of channels (sodium, potassium, calcium), and demonstrates antiadrenergic properties. Chemically, it is a benzofuran derivative. FDA approved on July 1, 2009.
InChI	InChI=1S/C31H44N2O5S/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3/h13-18,23,32H,5-12,19-22H2,1-4H3
InChIKey	InChIKey=ZQTNQVWKHCQYLQ-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_2149 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_2679
is metabolised by	http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0901
is substrate of	http://purl.obolibrary.org/obo/dinto_0217 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0901
label	dronedarone
may interact with	http://purl.obolibrary.org/obo/CHEBI_9948 http://purl.obolibrary.org/obo/CHEBI_4551 http://purl.obolibrary.org/obo/CHEBI_8499 http://purl.obolibrary.org/obo/CHEBI_101278 http://purl.obolibrary.org/obo/CHEBI_156095 http://purl.obolibrary.org/obo/CHEBI_70746 http://purl.obolibrary.org/obo/CHEBI_4031 http://purl.obolibrary.org/obo/CHEBI_61049 http://purl.obolibrary.org/obo/CHEBI_9150 http://purl.obolibrary.org/obo/CHEBI_7494 http://purl.obolibrary.org/obo/CHEBI_51364 http://purl.obolibrary.org/obo/dinto_DB01167 http://purl.obolibrary.org/obo/CHEBI_63115 http://purl.obolibrary.org/obo/CHEBI_681850 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/CHEBI_10119 http://purl.obolibrary.org/obo/CHEBI_39548 http://purl.obolibrary.org/obo/CHEBI_3732 http://purl.obolibrary.org/obo/CHEBI_6904 http://purl.obolibrary.org/obo/CHEBI_10033 http://purl.obolibrary.org/obo/CHEBI_45716 http://purl.obolibrary.org/obo/CHEBI_9168 http://purl.obolibrary.org/obo/dinto_DB00503 http://purl.obolibrary.org/obo/dinto_DB01026 http://purl.obolibrary.org/obo/CHEBI_195280 http://purl.obolibrary.org/obo/dinto_DB00976
modulates	http://purl.obolibrary.org/obo/dinto_4020 http://purl.obolibrary.org/obo/dinto_0234
prefixIRI	obo2:dinto_DB04855
prefLabel	dronedarone
related with	http://purl.obolibrary.org/obo/dinto_2907 http://purl.obolibrary.org/obo/dinto_2962 http://purl.obolibrary.org/obo/dinto_2965 http://purl.obolibrary.org/obo/dinto_3187 http://purl.obolibrary.org/obo/dinto_3475 http://purl.obolibrary.org/obo/dinto_3877 http://purl.obolibrary.org/obo/dinto_2957 http://purl.obolibrary.org/obo/dinto_2959 http://purl.obolibrary.org/obo/dinto_1581 http://purl.obolibrary.org/obo/dinto_2975 http://purl.obolibrary.org/obo/dinto_2979 http://purl.obolibrary.org/obo/dinto_1110 http://purl.obolibrary.org/obo/dinto_1027 http://purl.obolibrary.org/obo/dinto_1135
SMILES	CCCCN(CCCC)CCCOC1=CC=C(C=C1)C(=O)C1=C(CCCC)OC2=C1C=C(NS(C)(=O)=O)C=C2
Synonym	N-[2-butyl-3-({4-[3-(dibutylamino)propoxy]phenyl}carbonyl)-1-benzofuran-5-yl]methanesulfonamide C31H44N2O5S
xref	ChEBI:50659 ChemSpider:180996 PharmGKB:PA153619853 RxList:http://www.rxlist.com/multaq-drug.htm National Drug Code Directory:54868-3086-0 PubChem Substance:14861729 Drugs.com:http://www.drugs.com/ppa/dronedarone.html PubChem Compound:208898 Wikipedia:http://en.wikipedia.org/wiki/Dronedarone
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_50659	CHEBI	LOOM
http://purl.bioontology.org/ontology/RXNORM/233698	RXNORM	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/443195003	SNOMEDCT	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65485	NCIT	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000179804	NDFRT	LOOM
https://go.drugbank.com/drugs/DB04855	MDM	LOOM
http://purl.bioontology.org/ontology/VANDF/4028918	VANDF	LOOM
http://purl.bioontology.org/ontology/ATC/C01BD07	ATC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C118667	RH-MESH	LOOM
http://bmi.utah.edu/ontologies/hfontology/C0766326	HFO	LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass97f61dbe_c9ae_45f1_8524_d4ed470ecc0b	WWECA	LOOM
http://purl.bioontology.org/ontology/MESH/D000077764	MESH	LOOM
http://purl.obolibrary.org/obo/NCIT_C65485	BERO	LOOM
http://purl.bioontology.org/ontology/NDDF/013186	NDDF	LOOM
http://purl.obolibrary.org/obo/CHEBI_50659	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_50659	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_50659	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_50659	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_50659	DRON	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00025646	PMAPP-PMO	LOOM
http://www.drugbank.ca/drugs/DB04855	FTC	LOOM
http://purl.obolibrary.org/obo/CHEBI_50659	CHEBI	LOOM