The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

tiotropium
Synonyms

C19H22NO4S2

(1R,2S,4R,5S)-7-{[2-hydroxy-2,2-bis(thiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.0^{2,4}]nonan-9-ium

ID

http://purl.obolibrary.org/obo/dinto_DB01409

AHFScode

12:08.08

ATCCode

R03BB04

binds

http://purl.obolibrary.org/obo/dinto_1005

http://purl.obolibrary.org/obo/dinto_3182

http://purl.obolibrary.org/obo/dinto_3887

http://purl.obolibrary.org/obo/dinto_2993

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_2814

http://purl.obolibrary.org/obo/dinto_2789

blocks

http://purl.obolibrary.org/obo/dinto_3182

http://purl.obolibrary.org/obo/dinto_1005

http://purl.obolibrary.org/obo/dinto_3887

CASRN

186691-13-4

DBBrand

spiriva

DBSynonym

tiotropium bromide

Definition

Tiotropium is a long-acting, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). Tiotropium is a muscarinic receptor antagonist, on topical application it acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation, thus producing a bronchodilatory effect.

has effect

http://purl.obolibrary.org/obo/OAE_0000424

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0001373

http://purl.obolibrary.org/obo/OAE_0001437

http://purl.obolibrary.org/obo/OAE_0000659

http://purl.obolibrary.org/obo/OAE_0000596

http://purl.obolibrary.org/obo/OAE_0000406

http://purl.obolibrary.org/obo/OAE_0001509

http://purl.obolibrary.org/obo/OAE_0000900

http://purl.obolibrary.org/obo/OAE_0001489

http://purl.obolibrary.org/obo/OAE_0000567

http://purl.obolibrary.org/obo/OAE_0000319

http://purl.obolibrary.org/obo/OAE_0000608

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000375

http://purl.obolibrary.org/obo/OAE_0000455

http://purl.obolibrary.org/obo/OAE_0000498

http://purl.obolibrary.org/obo/OAE_0000502

http://purl.obolibrary.org/obo/OAE_0000584

http://purl.obolibrary.org/obo/OAE_0000533

http://purl.obolibrary.org/obo/OAE_0000355

http://purl.obolibrary.org/obo/OAE_0000789

http://purl.obolibrary.org/obo/OAE_0002122

http://purl.obolibrary.org/obo/OAE_0000508

http://purl.obolibrary.org/obo/OAE_0000343

http://purl.obolibrary.org/obo/OAE_0000505

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0000211

http://purl.obolibrary.org/obo/OAE_0000358

http://purl.obolibrary.org/obo/OAE_0000402

http://purl.obolibrary.org/obo/OAE_0000350

has pharmacological target

http://purl.obolibrary.org/obo/dinto_1005

InChI

InChI=1S/C19H22NO4S2/c1-20(2)12-9-11(10-13(20)17-16(12)24-17)23-18(21)19(22,14-5-3-7-25-14)15-6-4-8-26-15/h3-8,11-13,16-17,22H,9-10H2,1-2H3/q+1/t11?,12-,13+,16+,17-

InChIKey

InChIKey=LERNTVKEWCAPOY-KYQOMENCSA-N

is metabolised by

http://purl.obolibrary.org/obo/dinto_2993

http://purl.obolibrary.org/obo/dinto_0901

is substrate of

http://purl.obolibrary.org/obo/dinto_2993

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_2814

http://purl.obolibrary.org/obo/dinto_2789

is transported by

http://purl.obolibrary.org/obo/dinto_2814

http://purl.obolibrary.org/obo/dinto_2789

label

tiotropium

may interact with

http://purl.obolibrary.org/obo/dinto_DB00021

http://purl.obolibrary.org/obo/dinto_DB00209

http://purl.obolibrary.org/obo/dinto_DB01278

http://purl.obolibrary.org/obo/dinto_DB00427

http://purl.obolibrary.org/obo/CHEBI_27796

http://purl.obolibrary.org/obo/dinto_DB00382

http://purl.obolibrary.org/obo/dinto_DB00761

modulates

http://purl.obolibrary.org/obo/dinto_3182

http://purl.obolibrary.org/obo/dinto_1005

http://purl.obolibrary.org/obo/dinto_3887

prefixIRI

obo2:dinto_DB01409

prefLabel

tiotropium

SMILES

C[N+]1(C)[C@H]2CC(C[C@@H]1[C@@H]1O[C@H]21)OC(=O)C(O)(C1=CC=CS1)C1=CC=CS1

Synonym

C19H22NO4S2

(1R,2S,4R,5S)-7-{[2-hydroxy-2,2-bis(thiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.0^{2,4}]nonan-9-ium

xref

RxList:http://www.rxlist.com/cgi/generic/spiriva.htm

PharmGKB:PA164769056

Wikipedia:http://en.wikipedia.org/wiki/Tiotropium

Drugs.com:http://www.drugs.com/cdi/tiotropium.html

PubChem Substance:46504448

Drugs Product Database (DPD):2246793

PubChem Compound:3086654

National Drug Code Directory:0597-0075-75

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

Delete Subject Author Type Created
No notes to display